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Botulism: The Present Status of the Disease

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 195))

Abstract

Botulism is a very serious foodborne illness, often fatal, and characterized by neuroparalytic signs and symptoms. Early observations found an association with consumption of sausages, and thus the name botulism (derived from botulus, Latin for sausage) was given to the disease (Smith and Sugiyama 1988). Foodborne botulism is the result of ingestion of food containing neurotoxin produced by Clostridium botulinum. The disease may also result from toxin produced in vivo by organisms growing in an infected wound (wound botulism) or colonizing the intestinal tract (infant botulism).

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References

  • Arnon SS (1992a) Clinical trial of human botulism immune globulin. In: DasGupta BR (ed) Botulinum and tetanus neurotoxins: neurotransmission and biomedical aspects. Plenum, New York

    Google Scholar 

  • Arnon SS (1992b) Infant botulism. In: Feigen RD, Cherry JD (eds) Textbook of pediatric infectious diseases, 3rd edn. Saunders, Philadelphia

    Google Scholar 

  • Aureli P, Fenicia L, Pasolini B, Gianfranceschi M, McCroskey LM, Hatheway CL (1986) Two cases of type E infant botulism caused by neurotoxigenic Clostridium butyricum in Italy. J Infect Dis 154: 201–206

    Article  Google Scholar 

  • Aureli P, Fenicia L, Ferrini AM, Martini M, Beccia G (1992) Wound botulism: clinical and microbiological findings of an Italian case. Eur J Epidemiol 8: 750–752

    Article  PubMed  CAS  Google Scholar 

  • Barsanti JA, Walser M, Hatheway CL, Bowen JM, Crowell W (1978) Type C botulism in American foxhounds. J Am Vet Med Assoc 172: 809–813

    PubMed  CAS  Google Scholar 

  • Bengston IA (1924) Studies on organisms concerned as causative factors in botulism. Hyg Lab Bull 136 136:101

    Google Scholar 

  • Bernard W, Divers TJ, Whitlock RH, Messick J, Tulleners E (1987) Botulism as a sequel to open castration in a horse. J Am Vet Med Assoc 191: 73–74

    PubMed  CAS  Google Scholar 

  • Bizzini B (1989) Axoplasmic transport and transynaptic movement of tetanus toxin. In: Simpson LL (ed) Botulinum neurotoxin and tetanus toxin. Academic, San Diego

    Google Scholar 

  • Black RE, Gunn RA (1980) Hypersensitivity reactions associated with botulinal antitoxin. Am J Med 69: 567–570

    Article  PubMed  CAS  Google Scholar 

  • Cardella MA (1964) Botulinum toxoids. In: Lewis KH, Cassel K jr (eds) Botulism: proceedings of a symposium. US Department of Health, Education, and Welfare, Public Health Service (PHS Publ no 999 FP-1), Cincinnati

    Google Scholar 

  • Cato EP, George WL, Finegold SM (1986) Genus Clostridium. In: Sneath PHA, Mair NS, Sharpe ME, Holt JG (eds) Bergey’s manual of systematic bacteriology, vol 2. Williams and Wilkins, Baltimore

    Google Scholar 

  • CDC (1979) Botulism in the United States, 1899–1977. Handbook for epidemiologists, clinicians, and laboratory workers. CDC, Atlanta

    Google Scholar 

  • CDC (1993) Summary of notifiable diseases, United States 1992. MMWR 41 (55): 1–65

    Google Scholar 

  • Chia JK, Clark JB, Ryan CA, Pollack M (1986) Botulism in an adult associated with food-borne intestinal infection with Clostridium botulinum. N Engl J Med 315: 239–241

    Article  PubMed  CAS  Google Scholar 

  • Ciccarelli AS, Giulietti AM, Giménez GF (1976) Segunda cepa de Clostridium botulinum tipo G. Primer Congresso y IV Jomadas Argentinas de Microbiologia 21 (abstract)

    Google Scholar 

  • Corsi FM, DiBattista G, Galgani S, Piazza G (1979) Su un caso di botulismo da ferita. Riv Neurobiol 25: 200–205

    PubMed  CAS  Google Scholar 

  • Critchley EMR (1991) A comparison of human and animal botulism: a review. J R Soc Med 84: 295–298

    PubMed  CAS  Google Scholar 

  • Davis JB, Mattman LH, Wiley M (1951) Clostridium botulinum in a fatal wound infection. JAMA 146: 646–648

    Article  CAS  Google Scholar 

  • Demarchi J, Mourgues C, Oho J, Prevot AR (1958) Existence du-botulisme humain de type D. Bull Acad Natl Med 142: 580–582

    PubMed  CAS  Google Scholar 

  • DeVeze JL, Jougland J, LaBastie J, Sans P, Arditi J (1979) Botulisme d’inoculation: quand fautil y penser? Nouv Presse Med 8: 2755–2756

    PubMed  CAS  Google Scholar 

  • Divers TJ, Bartholomew RC, Messick JB, Whitlock RH, Sweeney RW (1986) Clostridium botulinum type B toxicosis in a herd of cattle and a group of mules. J Am Vet Med Assoc 188: 382–386

    PubMed  CAS  Google Scholar 

  • Dodds KL (1992a) Clostridium botulinum in the environment. In: Hauschild AHW, Dodds KL (eds) Clostridium botulinum: ecology and control in foods. Dekker, New York

    Google Scholar 

  • Dodds KL (1992b) Worldwide incidence and ecology of infant botulism. In: Hauschild AHW, Dodds KL (eds) Clostridium botulinum: ecology and control in foods. Dekker, New York

    Google Scholar 

  • Dowell VRJ, McCroskey LM, Hatheway CL, Lombard GL, Hughes JM, Merson MH (1977) Copro-examination for botulinal toxin and Clostridium botulinum. A new procedure for laboratory diagnosis of botulism. JAMA 238: 1829–1832

    Article  PubMed  Google Scholar 

  • Eklund MW, Dowell VR Jr (eds) (1987) Avian botulism: an international perspective. Thomas, Springfield

    Google Scholar 

  • Eklund MW, Poysky F, Oguma K, Iida H, Inoue K (1987) Relationship of bacteriophages to toxin and hemagglutinin production and its significance in avian botulism outbreaks. In: Eklund MW, Dowell VR Jr (eds) Avian botulism: an international perspective. Thomas, Springfield

    Google Scholar 

  • English WL, Williams LP, Bryant RE, Gillies MD (1981) Case 48–1980: botulism; letter to the editor. N Engl J Med 304: 789–790

    Google Scholar 

  • Fullerton P, Gogna NK, Stoddart R (1980) Wound botulism. Med J Aust 1: 662–663

    CAS  Google Scholar 

  • Giménez DF (1984) Clostridium botulinum subtype Ba. Zentralbl Bakteriol Hyg [A] 257: 68–72

    Google Scholar 

  • Giménez DF, Ciccarelli AS (1970) Another type of Clostridium botulinum. Zentralbl Bakteriol I Abt Orig A 215:221–224

    Google Scholar 

  • Griffin PM, Hatheway CL, Rosenbaum RB, Sokolow R (1994) Type A botulism due to intestinal colonization in an adult with Crohn’s disease associated with an immune response to the toxin. Manuscript in preparation

    Google Scholar 

  • Hall JD, McCroskey LM, Pincomb BJ, Hatheway CL (1985) Isolation of an organism resembling Clostridium barati which produces type F botulinal toxin from an infant with botulism. J din Microbiol 21:654–655

    CAS  Google Scholar 

  • Hatheway CL (1988) Botulism. In: Balows A, Hausler WH Jr, Ohashi M, Turano A (eds) Laboratory diagnosis of infectious diseases: principles and practice, vol 1. Springer, Berlin Heidelberg, New York

    Google Scholar 

  • Hatheway CL, McCroskey LM (1987) Examination of feces and serum for diagnosis of infant botulism in 336 patients. J Clin Microbiol 25: 2334–2338

    PubMed  CAS  Google Scholar 

  • Hatheway CL, McCroskey LM (1989) Unusual neurotoxigenic Clostridia recovered from human fecal specimens in the investigation of botulism. In: Hattori T, Ishida Y, Maruyama Y, Morita RY, Uchida A (eds) Proceedings of the 5th International Symposium on Microbiol Ecology: recent advances in microbiol ecology. Japan Scientific Societies, Tokyo

    Google Scholar 

  • Hatheway CL, McCroskey LM, Lombard GL, Dowell VRJ (1981) Atypical toxin variant of Clostridium botulinum type B associated with infant botulism. J Clin Microbiol 14: 607–611

    PubMed  CAS  Google Scholar 

  • Hatheway CL, Snyder JD, Seals JE, Edell TA, Lewis GE Jr (1984) Antitoxin levels in botulism patients treated with trivalent equine botulism antitoxin to toxin types A, B, and E. J Infect Dis 150: 407–412

    Article  PubMed  CAS  Google Scholar 

  • Hauschild AHW (1992) Epidemiology of human foodbome botulism. In: Hauschild AHW, Dodds KL (eds) Clostridium botulinum: ecology and control in foods. Dekker, New York

    Google Scholar 

  • Hughes JM, Blumenthal JR, Merson MH, Lombard GL, Dowell VR Jr, Gangarosa EJ (1981) Clinical features of type A and B food-borne botulism. Ann Intern Med 95: 442–445

    PubMed  CAS  Google Scholar 

  • Jensen WI, Price Jl (1987) The global importance of type C botulism in wild birds. In: Eklund MW, Dowell VR Jr (eds) Avian botulism: an international perspective. Thomas, Springfield

    Google Scholar 

  • Johnston J, Whitlock RH (1987) botulism. In: Robinson NE (ed) Current theraphy in equine medicine, 2nd edn. Saunders, Philadelphia

    Google Scholar 

  • Kempner W (1897) Weiterer Beitrag zur Lehre von der Fleischvergiftung. Das Antitoxin des Botulismus. Z Hyg Infektionskh 26: 481–500

    Article  Google Scholar 

  • Landmann G (1904) Ueber die Ursache der Darmstaedter Bohnenvergiftung. Hyg Rundsch 14:449–452

    Google Scholar 

  • Lee WH, Riemann H (1970a) Correlation of toxic and nontoxic strains of Clostridium botulinum by DNA composition and homology. J Gen Microbiol 60: 117–123

    PubMed  CAS  Google Scholar 

  • Lee WH, Riemann H (1970b) The genetic relatedness of proteolytic Clostridium botulinum strains. J Gen Microbiol 64: 85–90

    PubMed  CAS  Google Scholar 

  • Leuchs J (1910) Beitraege zur Kenntnis des Toxins und Antitoxins des Bacillus botulinus. Z Hyg Infektskh 65: 55–84

    Article  Google Scholar 

  • MacDonald KL, Spengler RF, Hatheway CL, Hargrett NT, Cohen ML (1985) Type A botulism from sauteed onions. JAMA 253: 1275–1278

    Article  PubMed  CAS  Google Scholar 

  • Mann JM, Hatheway CL, Gardiner TM (1982) Laboratory diagnosis in a large outbreak of type A botulism. Am J Epidemiol 115: 598–605

    PubMed  CAS  Google Scholar 

  • McCroskey LM, Hatheway CL (1988) Laboratory findings in four cases of adult botulism suggest colonization of the intestinal tract. J Clin Microbiol 26: 1052–1054

    PubMed  CAS  Google Scholar 

  • McCroskey LM, Hatheway CL, Fenicia L, Pasolini B, Aureli P (1986) Characterization of an organism that produces type E botulinal toxin but which resembles Clostridium butyricum from the feces of an infant with type E botulism. J Clin Microbiol 23: 201–202

    PubMed  CAS  Google Scholar 

  • McCroskey LM, Hatheway CL, Woodruff BA, Greenberg JA, Jurgenson P (1991) Type F botulism due to neurotoxigenic Clostridium baratii from an unknown source in an adult. J Clin Microbiol 29: 2618–2620

    PubMed  CAS  Google Scholar 

  • Merson MH, Dowell VR Jr (1973) Epidemiologic, clinical and laboratory aspects of wound botulism. N Engl J Med 289: 1105–1110

    Article  Google Scholar 

  • Meyer KF, Dubovsky BJ (1922) The distribution of spores of B. botulinus in the United States. J Infect Dis 31: 559–594

    Article  Google Scholar 

  • Midura TF, Arnon SS (1976) Infant botulism: identification of Clostridium botulinum and its toxin in faeces. Lancet ii: 934–936

    Article  Google Scholar 

  • Morris JG (1981) Current trends in theraphy of botulism in the United States. In: Lewis GE jr (ed) Biomedical aspects of botulism. Academic New York

    Google Scholar 

  • Nakamura S, Okado I, Nakashio S, Nishida S (1977) Clostridium sporogenes isolates and their relationship to C. botulinum based on deoxyribonucleic acid reassociation. J Gen Microbiol 100: 395–401

    PubMed  CAS  Google Scholar 

  • Nakamura S, Kimura I, Yamakawa K, Nishida S (1983) Taxonomic relationships among Clostridium novyi types A and B, Clostridium haemolyticum and Clostridium botulinum type C. J Gen Microbiol 129: 1473–1479

    PubMed  CAS  Google Scholar 

  • Notermans S, Nagel J (1989) Assays for botulinum and tetanus toxins. In: Simpson LL (ed) Botulinum neurotoxin and tetanus toxin. Academic San Diego

    Google Scholar 

  • Pickett J, Berg B, Chaplin E, Brunstetter MA (1976) Syndrome of botulism in infancy: clinical and electrophysiologic study. N Engl J Med 295: 770–772

    Article  PubMed  CAS  Google Scholar 

  • Prevot AR (1953) Rapport d’’introduction du President du Sous-Comite Clostridium pour l’ unification de la nomenclature des types toxigeniques de C. botulinum. Int Bull Bacteriol Nomenclature 3:120–123

    Article  Google Scholar 

  • Prevot AR, Terrasse J, Daumail J, Cavaroc M, Riol J, Sillioc R (1955) Existence en France du botulisme humain de type C. Bull Acad Med (Paris) 139: 355–358

    CAS  Google Scholar 

  • Richmond RN, Hatheway CL, Kaufmann AF (1978) Type C botulism in a dog. J Am Vet Med Assoc 173: 202–203

    PubMed  CAS  Google Scholar 

  • Seals JE, Snyder JD, Edell TA, Hatheway CL, Johnson CJ, Swanson RC, Hughes JM (1981) Restaurant associated type A botulism: transmission by potato salad. Am J Epidemiol 113: 436–444

    PubMed  CAS  Google Scholar 

  • Sebald M, Jouglard J (1977) Aspects actuels du botulisme. Rev Prat 27: 173–176

    PubMed  CAS  Google Scholar 

  • Sebald M, Saimot G (1973) Toxémie botulique: intérét de sa mise en évidence dans le diagnostic du botulisme humain de type B. Ann Microbiol (Inst Pasteur) 124A: 61–69

    Google Scholar 

  • Seddon HR (1922) Bulbar paralysis in cattle due to the action of a toxicogenic bacillus with a discussion of the relationship of the condition to forage poisoning (botulism). J Comp Pathol Ther 35:147–190

    Google Scholar 

  • Smith LDS (1978) The occurrence of Clostridium botulinum and Clostridium tetani in the soil of the United States. Health Lab Sci 15: 74–80

    PubMed  CAS  Google Scholar 

  • Smith LDS, Sugiyama H (1988) Botulism: the organism, its toxins, the disease, 2nd edn. Thomas, Springfield

    Google Scholar 

  • Sonnabend O, Sonnabend W, Heinzle R, Sigrist T, Dimhofer R, Krech U (1981) Isolation of Clostridium botulinum type G and identification of type G botulinal toxin in humans: report of five sudden unexpected deaths. J Infect Dis 143: 22–27

    Article  PubMed  CAS  Google Scholar 

  • Suen JC, Hatheway CL, Steigerwalt AG, Brenner DJ (1988a) Clostridium argentinense, sp. nov: a genetically homogenous group composed of all strains of Clostridium botulinum toxin type G and some nontoxigenic strains previously identified as Clostridium subterminale or Clostridium hastiforme. Int J Syst Bacteriol 38: 375–381

    Article  Google Scholar 

  • Suen JC, Hatheway CL, Steigerwalt AG, Brenner DJ (1988b) Genetic confirmation of identities of neurotoxigenic Clostridium baratii and Clostridium butyricum implicated as agents of infant botulism. J Clin Microbiol 26: 2191–2192

    PubMed  CAS  Google Scholar 

  • Swerczek TW (1980a) Experimentally induced toxicoinfectious botulism in horses and foals. Am J Vet Res 41: 348–350

    PubMed  CAS  Google Scholar 

  • Swerczek TW (1980b) Toxicoinfectious botulism in foals and adult horses. J Am Vet Med Assoc 176:217

    PubMed  CAS  Google Scholar 

  • Tacket CO, Shandera WX, Mann JM, Hargrett NT, Blake PA (1984) Equine antitoxin use and other factors that predict outcome in type A foodbome botulism. Am J Med 76: 794–798

    Article  PubMed  CAS  Google Scholar 

  • Terranova W, Breman JG, Locey RP, Speck S (1978) Botulism type B: epidemiologic aspects of an extensive outbreak. Am J Epidemiol 108: 150–156

    PubMed  CAS  Google Scholar 

  • Van Ermengem E (1897) Ueber einen neuen anaeroben Bacillus and seine Beziehungen zum Botulismus. Z Hyg Infektionskh 26: 1–56

    Article  Google Scholar 

  • Wainwright RB, Heyward WL, Middaugh JP, Hatheway CL, Harpster AP, Bender TR (1988) Foodborne botulism in Alaska, 1947–1985: epidemiology and clinical findings. J Infect Dis 157: 1158–1162

    Article  PubMed  CAS  Google Scholar 

  • Wang WJ, Wang LP (1983) Wound botulism: report of a case complicating a head injury. Chin J Med 96: 315–317

    CAS  Google Scholar 

  • Weber JT, Goodpasture HC, Alexander H, Werner SB, Hatheway CL, Tauxe RV (1993) Wound botulism in a patient with a tooth abcess: case report and review. Clin Infect Dis 16: 635–639

    Article  PubMed  CAS  Google Scholar 

  • Woodruff BA, Griffin PM, McCroskey LM, Smart JF, Wainwright RB, Bryant RG, Hutwagner LC, Hatheway CL (1992) Clinical and laboratory comparison of botulism from toxin types A, B, and E in the United States, 1975–1988. J Infect Dis 166: 1281–1286

    Article  PubMed  CAS  Google Scholar 

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Hatheway, C.L. (1995). Botulism: The Present Status of the Disease. In: Montecucco, C. (eds) Clostridial Neurotoxins. Current Topics in Microbiology and Immunology, vol 195. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85173-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-85173-5_3

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