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Convulsants Acting at the Inhibitory Glycine Receptor

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Part of the Springer Study Edition book series (volume 102)

Abstract

Inhibitory neurotransmission in the CNS is predominantly mediated by γ-aminobutyric acid (GABA) and glycine. Whereas GABAergic synapses are abundant in the cortex and cerebellum, glycine predominates in the spinal cord and brain stem (reviewed by Betz and Becker 1988; Langosch et al. 1990a,b). Glycine-mediated synaptic inhibition was first demonstrated in the spinal cord where, at the segmental level, neuronal pathways regulate the tonus of skeletal muscle (reviewed by Krnjevic 1981; Aprison 1990). Glycinergic synapses prevail in the spinal sensory, auditory, and visual system and in other parts of the CNS.

Keywords

  • GABAA Receptor
  • Glycine Receptor
  • Xenopus Laevis Oocyte
  • Spinal Cord Neuron
  • Convulsant Acting

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This work was supported by Deutsche Forschungsgemeinschaft (SFB 317 and Heisenberg-Programm).

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Becker, CM. (1994). Convulsants Acting at the Inhibitory Glycine Receptor. In: Herken, H., Hucho, F. (eds) Selective Neurotoxicity. Springer Study Edition, vol 102. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85117-9_15

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