Convulsants Acting at the Inhibitory Glycine Receptor

  • C.-M. Becker
Part of the Springer Study Edition book series (volume 102)

Abstract

Inhibitory neurotransmission in the CNS is predominantly mediated by γ-aminobutyric acid (GABA) and glycine. Whereas GABAergic synapses are abundant in the cortex and cerebellum, glycine predominates in the spinal cord and brain stem (reviewed by Betz and Becker 1988; Langosch et al. 1990a,b). Glycine-mediated synaptic inhibition was first demonstrated in the spinal cord where, at the segmental level, neuronal pathways regulate the tonus of skeletal muscle (reviewed by Krnjevic 1981; Aprison 1990). Glycinergic synapses prevail in the spinal sensory, auditory, and visual system and in other parts of the CNS.

Keywords

Neurol Imipramine Pyrazole Lactam Pregnenolone 

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© Springer-Verlag Berlin Heidelberg 1994

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  • C.-M. Becker

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