Abstract
In the intact rat sciatic nerve the nonneuronal cells surrounding the axons synthesize very low amounts of nerve growth factor (NGF). After cutting the nerve there is a biphasic increase in levels of NGF-mRNA in the distal nerve segment and in the tip of the proximal stump where axonal regrowth is initiated. The rapid transient increase of NGF-mRNA (first phase) is preceded by an almost immediate elevation in the levels of the mRNAs coding for the nuclear protooncogenes c-fos and c-jun. A trans-activating effect of FOS on the NGF-promoter was demonstrated by using sciatic nerve derived fibroblasts carrying an exogenous inducible fos gene. Further analysis shows that an AP-1 consensus sequence located in the first intron of the NGF gene is essential for the fos-mediated increase of NGF-mRNA levels.
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© 1994 Springer-Verlag
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Heumann, R., Hengerer, B., Brown, M., Perry, H., Markus, A., Borasio, G.D. (1994). Role of Oncogenes in Neural Regeneration. In: Stennert, E.R., Kreutzberg, G.W., Michel, O., Jungehülsing, M. (eds) The Facial Nerve. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85090-5_18
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DOI: https://doi.org/10.1007/978-3-642-85090-5_18
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