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Hereditary and Familial Ovarian Cancer

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Familial and Hereditary Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 136))

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Abstract

Ovarian cancer is a common and frequently lethal condition, especially in well-developed and industrialized countries. The disease shows several analogies with breast carcinoma, and both neoplasms represent examples of probable, or possible, interaction between environmental and genetic factors in tumor promotion and progression. Thus, hormonal and reproductive factors are thought to be of some pathogenetic relevance in breast as well as in ovarian carcinoma, and a “risk profile” can tentatively be traced for both neoplasms. Many of these factors are closely related to modern habits and lifestyle; interestingly, some of these factors (i.e., oral contraceptives) might actually be protective against ovarian cancer development.

As far as we can determine, there is no one at greater risk for ovarian cancer than a patient who is in the direct genetic lineage of a hereditary ovarian cancer syndrome kindred and whose mother, sister, and/or daughter is affected with this disease and/or an integrally related syndrome cancer. H. T. Lynch et al. (1991)

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  1. Istituto di Patologia Medica Policlinico, Università degli Studi di Modena, Via del Pozzo, 71, 41100, Modena, Italy

    Prof. Dr. M. Ponz de Leon

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© 1994 Springer-Verlag Berlin Heidelberg

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de Leon, M.P. (1994). Hereditary and Familial Ovarian Cancer. In: Familial and Hereditary Tumors. Recent Results in Cancer Research, vol 136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85076-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-85076-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85078-3

  • Online ISBN: 978-3-642-85076-9

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