Epidemiological Aspects of Hypercalcemia of Malignancy
Hypercalcemia can be caused by many disorders, but is most commonly due to primary hyperparathyroidism and to malignant disease. Together, these account for more than 90% of all cases. Many patients with primary hyperparathyroidism are asymptomatic and ambulant when hypercalcemia is first recognized by routine measurement of serum calcium levels. However, the incidence of hypercalcemia of cancer, which has been estimated to be about 150 new cases per million persons per year, is not as high as the annual incidence rate of primary hyperparathyroidism (approximately 250 new cases per year) (Burkhardt and Kistler 1981; Heath et al. 1980; Mundy et al. 1980, 1984).
KeywordsMultiple Myeloma Bone Metastasis Primary Hyperparathyroidism Epidemiological Aspect Humoral Hypercalcemia
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- Bundred NJ, Ratcliffe WA, Walker RA, Coley S, Morrison JM, Ratcliffe JR (1991) Parathyroid hormone related protein and hypercalcemia in breast cancer. Br J Cancer 303:1506–1509Google Scholar
- Coleman RL, Fogelman I, Rubens RD (1988) Hypercalcemia and breast cancer: an increased humoral component in patients with liver metastases. Eur J Surg Oncol 14:428–443Google Scholar
- Grossmann B, Schechter GP, Horton JE, Pierce L, Juffe E, Wahl L (1981) Hypercalcemia associated with T-cell lymphoma-leukemia. Am J Clin Pathol 75: 149–155Google Scholar
- Myers WPL (1973) Hypercalcemia associated with maligant diseases. In: Schwartz TB (ed) Endocrine and nonendocrine hormone-producing tumors. Year Book Medical Publishers, Chicago, pp 147–171Google Scholar