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Humoral Hypercalcemia of Malignancy: Role of Parathyroid Hormone-Related Protein

  • Chapter
Hypercalcemia of Malignancy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 137))

Abstract

Hypercalcemia is a frequent complication of many types of malignancy (Mundy 1985). The humoral form of the syndrome (humoral hypercalcemia of malignancy, HHM) causes hypercalcemia without necessarily metastasizing to the bone and shares several biochemical features with primary hyperparathyroidism (pHPT), such as hypercalcemia and hypophosphatemia in plasma, and decreased renal reabsorption of phosphorus. An excess of parathyroid hormone (PTH) is, of course, the cause of hypercalcemia in pHPT, leading F. Albright more than half a century ago to the suggestion that PTH or a PTH-like factor might be involved in HHM. In the 1970s, with the availability of PTH immunoassays, it became evident that PTH itself usually was not the factor responsible for HHM.

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  1. Department of Internal Medicine I — Endocrinology and Metabolism, University of Heidelberg, Bergheimerstraße 58, 69115, Heidelberg, Germany

    E. Blind

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  1. Innere Medizin I, Medizinische Universitätsklinik, Bergheimer Straße 58, 69115, Heidelberg, Germany

    F. Raue

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Blind, E. (1994). Humoral Hypercalcemia of Malignancy: Role of Parathyroid Hormone-Related Protein. In: Raue, F. (eds) Hypercalcemia of Malignancy. Recent Results in Cancer Research, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85073-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-85073-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85075-2

  • Online ISBN: 978-3-642-85073-8

  • eBook Packages: Springer Book Archive

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