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Cytokines as Mediators of Hypercalcemia of Malignancy

  • Chapter
Hypercalcemia of Malignancy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 137))

Abstract

Hypercalcemia of malignancy is due to the breakdown of the normal regulation of calcium homeostasis. It is caused by an abnormally large production of one or several cytokines and/or other regulatory factors by the tumor cells capable of influencing the effectors of calcium homeostasis. There is little doubt that calcium release from bone contributes greatly to the hypercalcemia seen with humoral hypercalcemia of malignancy. Bone resorption is also certainly the major contributing factor in the hypercalcemia observed with many hematologic diseases or local bone metastases. In this chapter I will focus on the role of cytokines in this type of tumor-increased bone resorption, although one should be fully aware that increased calcium reabsorption from the kidney or increased calcium absorption from the intestinal tract may contribute to a variable degree to the whole picture of hypercalcemia of malignancy.

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Authors and Affiliations

  1. Department of Internal Medicine I, — Endocrinology and Metabolism, University of Heidelberg, Bergheimerstraße 58, 69115, Heidelberg, Germany

    J. Pfeilschifter

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  1. J. Pfeilschifter
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  1. Innere Medizin I, Medizinische Universitätsklinik, Bergheimer Straße 58, 69115, Heidelberg, Germany

    F. Raue

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© 1994 Springer-Verlag Berlin Heidelberg

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Pfeilschifter, J. (1994). Cytokines as Mediators of Hypercalcemia of Malignancy. In: Raue, F. (eds) Hypercalcemia of Malignancy. Recent Results in Cancer Research, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85073-8_1

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  • DOI: https://doi.org/10.1007/978-3-642-85073-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85075-2

  • Online ISBN: 978-3-642-85073-8

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