Catabolism — Potential for Amelioration by Growth Factors
Trauma, sepsis and surgery are characterized by the development of a catabolic state with net breakdown of protein, carbohydrate and fat to meet increased energy demands and to supply the metabolic fuels required for gluconeogenesis and acute phase protein synthesis. Prolonged or more severe metabolic stress can overwhelm the ability of the body to supply these endogenous substrates; such self-destructive autocannibalism  results in muscle wasting, an impaired immune response and prolonged hospital admission .
KeywordsCecal Ligation Caecal Ligation Acute Phase Protein Synthesis Biosynthetic Human Growth Hormone Severe Metabolic Stress
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