The Protective Role of Interleukin-10 in Sepsis
It is currently admitted that the production of inflammatory cytokines, such as tumor necrosis factor (TNF) and interleukin-1 (IL-1) plays a central role in the pathogenesis of septic shock . So far, the mechanisms controlling inflammatory cytokine release in vivo are poorly understood. The production of corticosteroids, a potent inhibitor of cytokine release by activated macrophages, could be one mechanism controlling cytokine release during gram-negative sepsis as suggested by the increased sensitivity of adrenalectomized mice to lipopolysaccharide (LPS) toxicity . This chapter will discuss data showing that IL-10, a recently described cytokine inhibiting TNF production by LPS-activated macrophages, is released during murine endotoxemia and protects mice from LPS toxicity. We well also show that IL-10 is produced during human septicemia and septic shock and discuss the possible role of IL-10 as a protective cytokine in this setting.
KeywordsToxicity Corticosteroid Interferon Glucocorticoid Cyclosporin
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- 10.de Waal Malefyt R, Yssel H, Roncarolo MG, Spits H, de Vries JE (1992) Interleukin-10 Curr Opin Immunol 4: 314–320Google Scholar
- 21.Marchant A, Bruyns C, Vandenabeele P, et al (1993) Interleukin-10 differentially regulates cytokine production during murine endotoxin shock. 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, 12 (Abst)Google Scholar
- 27.Marchant A, Bruyns C, Vandenabeele P, et al (1993) Endogenous IL-10 protects mice against endotoxin shock. IVth International Conference on Endotoxins, Amsterdam, 0 35 (Abst)Google Scholar
- 30.Fantuzzi G, Marchant A, Sironi M, et al (1993) Chlorpromazine differentially regulates TNF, IL-6 and IL-10 release during murine endotoxemia. IVth International Conference on Endotoxins, Amsterdam P 30 (Abst)Google Scholar
- 31.Marchant A, Bruyns C, Abramovicz D, et al (1993) Differential regulation of IL-10, IL-6 and TNF release by pentoxifylline during murine endotoxemia. IVth International Conference on Endotoxins, Amsterdam P 33 (Abst)Google Scholar