The Protective Role of Interleukin-10 in Sepsis
It is currently admitted that the production of inflammatory cytokines, such as tumor necrosis factor (TNF) and interleukin-1 (IL-1) plays a central role in the pathogenesis of septic shock . So far, the mechanisms controlling inflammatory cytokine release in vivo are poorly understood. The production of corticosteroids, a potent inhibitor of cytokine release by activated macrophages, could be one mechanism controlling cytokine release during gram-negative sepsis as suggested by the increased sensitivity of adrenalectomized mice to lipopolysaccharide (LPS) toxicity . This chapter will discuss data showing that IL-10, a recently described cytokine inhibiting TNF production by LPS-activated macrophages, is released during murine endotoxemia and protects mice from LPS toxicity. We well also show that IL-10 is produced during human septicemia and septic shock and discuss the possible role of IL-10 as a protective cytokine in this setting.
KeywordsTumor Necrosis Factor Septic Shock Endotoxic Shock Endotoxin Shock Tumor Necrosis Factor Production
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