The Protective Role of Interleukin-10 in Sepsis

  • A. Marchant
  • J. L. Vincent
  • M. Goldman
Part of the Yearbook of Intensive Care and Emergency Medicine 1994 book series (YEARBOOK, volume 1994)


It is currently admitted that the production of inflammatory cytokines, such as tumor necrosis factor (TNF) and interleukin-1 (IL-1) plays a central role in the pathogenesis of septic shock [1]. So far, the mechanisms controlling inflammatory cytokine release in vivo are poorly understood. The production of corticosteroids, a potent inhibitor of cytokine release by activated macrophages, could be one mechanism controlling cytokine release during gram-negative sepsis as suggested by the increased sensitivity of adrenalectomized mice to lipopolysaccharide (LPS) toxicity [2]. This chapter will discuss data showing that IL-10, a recently described cytokine inhibiting TNF production by LPS-activated macrophages, is released during murine endotoxemia and protects mice from LPS toxicity. We well also show that IL-10 is produced during human septicemia and septic shock and discuss the possible role of IL-10 as a protective cytokine in this setting.


Tumor Necrosis Factor Septic Shock Endotoxic Shock Endotoxin Shock Tumor Necrosis Factor Production 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. Marchant
  • J. L. Vincent
  • M. Goldman

There are no affiliations available

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