Administration of Methylene Blue in Septic Shock: Is it Beneficial?

  • J. C. Preiser
  • H. Zhang
  • J. L. Vincent
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine 1994 book series (YEARBOOK, volume 1994)


Nitric oxide (NO) is released in massive amounts following exposure of isolated vessels, isolated organs or intact animals to a septic challenge, represented by bacterial lipopolysaccharide (LPS), exotoxin, cytokines, or supernatant from activated neutrophils or macrophages. By its potent vasodilating action, and also its negative inotropic effects, NO has been incriminated in the hemodynamic disturbances of severe sepsis or septic shock. However, NO also plays a role in the maintenance of peripheral tissue perfusion (through vascular relaxation and inhibition of platelet aggregation), in the intercellular adhesion and in the macrophage-mediated response to some microorganisms and tumors.


Nitric Oxide Nitric Oxide Septic Shock Methylene Blue Methylene Blue 
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© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • J. C. Preiser
  • H. Zhang
  • J. L. Vincent

There are no affiliations available

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