The Anti-Hu Syndrome: A Model Paraneoplastic Disorder

  • J. B. Posner
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 135)


In 1948 Derek Denny-Brown, one of the major figures in twentieth century neurology, published a paper describing two patients with a rapidly developing sensory neuropathy [1]. The pathological abnormalities included an inflammatory degeneration of neurons in the dorsal root ganglia and small cell lung cancer that had not metastasized to the nervous system. Although paraneoplastic syndromes affecting the nervous system had been described in occasional case reports as far back as the last century [2,3], and although a subacutely developing sensory neuropathy associated with occult cancer had also been described previously [4], Denny-Brown’s careful clinical and pathological description was a major contribution, generating interest in these rare but physiologically interesting nervous system disorders. (This despite an almost certainly incorrect hypothesis that the tumor and the nervous system were competing for an essential substrate; he believed it to be pantothenic acid.)


Dorsal Root Ganglion Purkinje Cell Small Cell Lung Cancer Cerebral Spinal Fluid Sensory Neuropathy 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • J. B. Posner
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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