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The O-2A Lineage: From Rats to Humans

  • Conference paper
Molecular Neuro-oncology and Its Impact on the Clinical Management of Brain Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 135))

Abstract

One aspect of our research programme has been to develop an analysis of precursor division and differentiation sufficiently detailed to allow growth of purified precursor cells in a manner compatible with subsequent transplantation of these cells into demyelinated lesions of the adult CNS. Accomplishment of this goal has required identification of the precursor cells for oligodendrocytes, elucidation of the cellular and molecular interactions which regulate the differentiation of these precursors and development of strategies for growing highly enriched precursor populations in a manner suitable for use in transplantation experiments.

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References

  • Bögler O, Wren D, Barnett SC, Land H, Noble M (1990) Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of O-2A progenitor cells. Proc Natl Acad Sci USA 87: 6368–6372

    Article  PubMed  Google Scholar 

  • Compston DAS, Scolding NJ, Wren DR, Noble M (1991) The pathogenesis of demyelinating disease: insights from cell biology. Trends Neurosci 14: 175–182

    Article  PubMed  CAS  Google Scholar 

  • Crang AJ, Franklin JRM, Blakemore WF, Noble M, Barnett SC, Groves A, Trotter J, Schachner M (1992) The differentiation of glial cell progenitor populations following transplantation into non-repairing CNS glial lesions in adult animals. J Neuroimmunol 40: 243–254

    Article  PubMed  CAS  Google Scholar 

  • Cross M, Dexter TM (1991) Growth factors in development transformation and tumorigenesis. Cell 64: 271–280

    Article  PubMed  CAS  Google Scholar 

  • David S, Miller RH, Patel R, Raff MC (1984) Effects of neonatal transection on glial cell development in the rat optic nerve: Evidence thta the oligodendrocyte-type 2 astrocyte cell lineage depends on axons for its survival. J Neurocytol 13: 961–974

    Article  PubMed  CAS  Google Scholar 

  • Eccleston A, Silberberg DR (1985) Fibroblast growth factor is a mitogen for oligodendrocytes in vitro. Dev Brain Res 21: 315–318

    Article  Google Scholar 

  • Fulton BP, Burne JF, Raff MC (1991) Glial cells in the rat optic nerve: The search for the type 2 astrocytes. Ann NY Acad Sci 633: 27–34

    Article  PubMed  CAS  Google Scholar 

  • Gard AL, Pfeiffer SE (1990) Two proliferative stages of the oligodendrocyte lineage: (A2B5+04- and 04+GaIC-) under different mitogenic control. Neuron 5: 615–625

    Article  PubMed  CAS  Google Scholar 

  • Godfraind C, Friedrich VL, Holmes KV, Dubois-Dalcq M (1989) In vivo analysis of glial cell phenotypes during a viral demyelinating disease in mice. J Cell Biol 109: 2405–2416

    Article  PubMed  CAS  Google Scholar 

  • Groves A, Bögler O, Jat P, Noble M (1991) The cellular measurement of time. Curr Opin Cell Biol 3: 224–229

    Article  PubMed  CAS  Google Scholar 

  • Groves AK, Barnett SC, Franklin RIM, Crong AJ, Mayer M, Blakemore WF, Noble M (1993) Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells. Nature 362: 453–455

    Article  PubMed  CAS  Google Scholar 

  • Hunter SF, Bottenstein JE (1991) O-2A glial progenitors from mature brain respond to CNS neuronal cell line-derived growth factors. J Neurosci Res 28: 574–582

    Article  PubMed  CAS  Google Scholar 

  • Kriss A, Francis DA, Cuendet F, Halliday AM, Taylor DS, Wilson J, Keast Butler J, Batchelor JR, McDonald WI (1988) Recovery after optic neuritis in childhood. J Neurol Neurosurg Psychiatr 51: 1253–1258

    Article  PubMed  CAS  Google Scholar 

  • Logan A (1988) Elevation of acidic fibroblast growth factors in lesioned rat brain. Mol Cell Endocrinol, 58: 275–278

    Article  PubMed  CAS  Google Scholar 

  • Lotan M, Schwarz M (1992) Postinjury changes in platelet derived growth factor-like activity in fish and rat optic nerves: possible implications in regeneration. J Neurochem 58: 1637–1642

    Article  PubMed  CAS  Google Scholar 

  • Matsoi Y, Zsebo K, Hogan BL (1992) Derivation of pluri potential embryonic stem cells from murine primordial gem cells in culture. Cell 70: 841–847

    Article  Google Scholar 

  • Mayer M, Noble M (1992) The inhibition of oligodendrocytic differentiation of O-2A progenitors caused by basic fibroblast growth factor is overridden by astrocytes. Glia 8: 12–19

    Article  Google Scholar 

  • Mayer M, Bhakoo K, Noble M (1994) Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, survival and maturation of oligo dendrocytes in vitro. Development (in press)

    Google Scholar 

  • McKinnon RD, Matsui T, Dubois-Dalcq M, Aaronson SA (1990) FGF modulates the PDGF-driven pathway of oligodendrocyte development. Neuron 5: 603–614

    Article  PubMed  CAS  Google Scholar 

  • Miller RH, David S, Patel ER, Raff MC (1985) A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: In vivo evidence for two distinct astrocyte lineages. Dev Biol 111: 35–43

    Article  PubMed  CAS  Google Scholar 

  • Nietro-Sampedro M, Lim R, Hicklin DJ, Cotman CW (1988) Early release of glia maturation factor, acidic fibroblast growth factor after rat brain injury. Neurosci Lett 86: 361–365

    Article  Google Scholar 

  • Noble M (1991) Points of controversy in the O-2A lineage: Clocks and type-2 astrocytes. Glia 4: 157–164

    Article  PubMed  CAS  Google Scholar 

  • Noble M, Murray K (1984) Purified astrocytes promote the division of a bipotential glial progenitor cell. EMBO J1 3: 2243–2247

    Google Scholar 

  • Noble M, Murray K, Stroobant P, Waterfield M, Riddle P (1988) Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte-type-2 astrocyte progenitor cell. Nature 333: 560–562

    Article  PubMed  CAS  Google Scholar 

  • Noble M, Ataliotis P, Barnett SC, Bevan K, Bögler O, Wolswijk PG, Wren D (1991) Development differentiation and neoplasia in glial cells of the central nervous system Ann NYAS 633: 35–47

    CAS  Google Scholar 

  • Pringle N, Collarini EJ, Mosley MJ, Heldin C-H, Westermark B, Richardson WD (1989) PDGF A chain homodimers drive proliferation of bipotential: (O-2A) glial progenitor cells in the developing rat optic nerve EMBO J 8: 1049–1056

    CAS  Google Scholar 

  • Raff MC (1989) Glial cell diversification in the rat optic nerve. Science 243: 1450–1455

    Article  PubMed  CAS  Google Scholar 

  • Raff MC, Abney ER, Cohen J, Lindsay R, Noble M (1983a) Two types of astrocytes in cultures of developing rat white matter: differences in morphology surface properties and growth characteristics. J Neurosci 3: 1289–1300

    PubMed  CAS  Google Scholar 

  • Raff MC, Miller RH, Noble M (1983b) A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on the culture medium. Nature 303: 390–396

    Article  PubMed  CAS  Google Scholar 

  • Raff MC, Miller RH, Noble M (1983c) Glial cell lineages in the rat optic nerve. Cold Spring Harbor Symp Quant Biol 48: 569–572

    PubMed  Google Scholar 

  • Raff MC, Abney ER, Fok-Seang J (1985) Reconstitution of a developmental clock in vitro: A critical role for astrocytes in the timing of oligodendrocyte differentiation. Cell 42: 61–69

    Article  PubMed  CAS  Google Scholar 

  • Raff MC, Lillien LE, Richardson WD, Burne JF, Noble MD (1988) Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture. Nature 333: 562–565

    Article  PubMed  CAS  Google Scholar 

  • Richardson WD, Pringle N, Mosley MJ, Westermark B, Dubois-Dalcq M (1988) A role for plateletderived growth factor in normal gliogenesis in the central nervous system. Cell 53: 309–319

    Article  PubMed  CAS  Google Scholar 

  • Richardson WD, Raff M, Noble M (1991) The oligodendrocyte-type-2 astrocyte cell lineage. Semin Neurosci 2: 445–454

    Google Scholar 

  • Saneto RP, DeVellis J (1985) Characterization of cultured rat oligodendrocytes proliferating in a serum-free chemically defined medium. Proc Natl Acad Sci USA 82: 3509–3513

    Article  PubMed  CAS  Google Scholar 

  • Sasahara M, Fries JWU, Raines EW, Gown AM, Westrum LE, Frosch MP, Bonthron DT, Ross R, Collins T (1991) PDGF B-chain in neurons of the central nervous system posterior pituitary and in a transgenic model. Cell 64: 217–227

    Article  PubMed  CAS  Google Scholar 

  • Scolding NJ, Morgan BP, Houston A, Campbell AK, Linington C, Compston DAS (1989) Normal rat serum cytotoxicity against syngeneic oligodendrocytes. J Neurol Sci 89: 289–300

    Article  PubMed  CAS  Google Scholar 

  • Skoff RP, Price DL, Stocks A (1976a) Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve 1 Cell proliferation. J Comp Anat 169: 291–311

    CAS  Google Scholar 

  • Skoff RP, Price DL, Stocks A (1976b) Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve 2 Time of origin. J Comp Anat 169: 313–323

    CAS  Google Scholar 

  • Skoff RP, Knapp PE (1991) Division of astroblasts and oligodendroblasts in postnatal rodent brain: Evidence for separate astrocyte and oligodendrocyte lineages Glia 4: 165–174

    CAS  Google Scholar 

  • Small R, Riddle P, Noble M (1987) Evidence for migration of oligodendrocyte-type-2 astrocyte progenitor cells into the developing rat optic nerve. Nature 328: 155–157

    Article  PubMed  CAS  Google Scholar 

  • Temple S, Raff MC (1986) Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions. Cell 44: 773–779

    Article  PubMed  CAS  Google Scholar 

  • Urenjak J, Williams S, Gadian D, Noble M (1992) Specific expression of N-acetyl-aspartate in neurones O-2A progenitors and immature oligodendrocytes in vitro. J Neurochem 59: 55–61

    Article  PubMed  CAS  Google Scholar 

  • Urenjak J, Williams S, Gadian D, Noble M (1992) Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 13: 981–989

    Google Scholar 

  • Vaysse PJ-J, Goldman JE (1990) A clonal analysis of glial lineages in neonatal forebrain development in vitro. Neuron 5: 227–235

    Article  PubMed  CAS  Google Scholar 

  • Wolswijk G, Noble M (1989) Identification of an adult-specific glial progenitor cell Development. 105: 387–400

    CAS  Google Scholar 

  • Wolswijk G, Riddle P, Noble M (1990) Co-existence of perinatal and adult forms of a ghat progenitor cell during development of the rat optic nerve. Development 109: 691–698

    PubMed  CAS  Google Scholar 

  • Wolswijk G, Riddle P, Noble M (1991) Platelet-derived growth factor is mitogenic for 0–2Aadult progenitor cells. Glia 4: 495–503

    Article  PubMed  CAS  Google Scholar 

  • Wolswijk G Noble M (1992) Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of their perinatal counterparts. J Cell Biol 118: 889–900

    Article  PubMed  CAS  Google Scholar 

  • Wren D, Noble M (1989) Oligodendrocytes and oligodendrocyte-type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody. Proc Natl Acad Sci USA 86: 9025–9029

    Article  PubMed  CAS  Google Scholar 

  • Wren D, Wolswijk G, Noble M (1992) In vitro analysis of origin and maintenance of O-2Aadult progenitor cells. J Cell Biol 116: 167–176

    Article  PubMed  CAS  Google Scholar 

  • Yeh J-J, Ruit KG, Wang Y-X, Parks WC, Snider WD, Deuel TF (1991) PDGF A-chain is expressed by mammalian neurons during development and in maturity. Cell 64: 209–219

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Ludwig Institute for Cancer Research, 91 Riding House St., London, W1P 8BT, UK

    M. Noble

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  1. M. Noble
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Editor information

Editors and Affiliations

  1. Institut für Neuropathologie, Universitätskliniken Bonn, Sigmund-Freud-Straße 25, 53105, Bonn, Germany

    O. D. Wiestler

  2. Neurologische Universitätsklinik, Sigmund-Freud-Straße 25, 53105, Bonn, Germany

    U. Schlegel  & J. Schramm  & 

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© 1994 Springer-Verlag Berlin Heidelberg

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Noble, M. (1994). The O-2A Lineage: From Rats to Humans. In: Wiestler, O.D., Schlegel, U., Schramm, J. (eds) Molecular Neuro-oncology and Its Impact on the Clinical Management of Brain Tumors. Recent Results in Cancer Research, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85039-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-85039-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85041-7

  • Online ISBN: 978-3-642-85039-4

  • eBook Packages: Springer Book Archive

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