Human Neuroblastoma: Amplification of the N-myc Oncogene and Loss of a Putative Cancer-Preventing Gene on Chromosome 1p
The nervous system is the most common site for the development of solid neoplasms in childhood. Neuroblastoma represents a tumor developing at peripheral sites from primitive neuroectodermal cells derived from the neural crests. It very often has a rapidly progressive clinical course. Many advances have been made in understanding the genesis and biology of this tumor which have been translated into better clinical management; however, little improvement in survival rates has been achieved, at least for the large group of patients who have metastatic tumor.
KeywordsMalignant Mesothelioma Human Neuroblastoma Cell Alveolar Rhabdomyosarcoma Cellular Oncogene Oncogene Amplification
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