Human Neuroblastoma: Amplification of the N-myc Oncogene and Loss of a Putative Cancer-Preventing Gene on Chromosome 1p
The nervous system is the most common site for the development of solid neoplasms in childhood. Neuroblastoma represents a tumor developing at peripheral sites from primitive neuroectodermal cells derived from the neural crests. It very often has a rapidly progressive clinical course. Many advances have been made in understanding the genesis and biology of this tumor which have been translated into better clinical management; however, little improvement in survival rates has been achieved, at least for the large group of patients who have metastatic tumor.
KeywordsCodon Recombination Electrophoresis Serine Oncol
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