Abstract
Malignant gliomas remain poorly responsive to conventional treatment consisting of surgical resection followed by external beam radiation therapy. Moreover, systemic chemotherapy has been generally disappointing in prolonging the survival of patients with malignant brain tumors, except for those with anaplastic oligodendrogliomas, where more encouraging results have recently been reported. The significant systemic toxicity associated with the large doses of chemotherapeutic agents required and the poor delivery of anticancer agents to areas of the brain “protected” by the blood-brain barrier are likely responsible for the limited effectiveness of chemotherapy.
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© 1994 Springer-Verlag Berlin · Heidelberg
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Olivi, A., Brem, H. (1994). Interstitial Chemotherapy with Sustained-Release Polymer Systems for the Treatment of Malignant Gliomas. In: Wiestler, O.D., Schlegel, U., Schramm, J. (eds) Molecular Neuro-oncology and Its Impact on the Clinical Management of Brain Tumors. Recent Results in Cancer Research, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85039-4_15
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DOI: https://doi.org/10.1007/978-3-642-85039-4_15
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