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Chemotherapy of Malignant Gliomas

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Book cover Molecular Neuro-oncology and Its Impact on the Clinical Management of Brain Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 135))

Abstract

Cure of primary malignant brain tumors today may be expected only in childhood in about 50% of medulloblastomas or primitive neuroectodermal tumors (PNETs), whereas in most other childhood tumors and in adults after 5 years a finally lethal relapse must be accounted for. The concept of primary multimodal treatment of brain tumors aims, however, at cure. Until now there is no controlled trial to compare overall survival after adjuvant postoperative chemotherapy with a palliative chemotherapy beginning only at the time of relapse.

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References

  1. Adelstein DJ, Likavec MJ, Sharan VM, White RJ, Takaoka SG, Carter SG, Hines JD (1987) Intravenous 5-fluorouracil infusion and simultaneous radiotherapy in glioblastoma multiforme. ASCO Proc 6: 274

    Google Scholar 

  2. Afra D (1973) Vincristine therapy in malignant glioma recurrencies. Neurochirurgia 16: 189–198

    PubMed  CAS  Google Scholar 

  3. Afra D, Kocsis B, Dobay J, Eckhardt S (1983) Combined radiotherapy and chemotherapy with dibromodulcitol and CCNU in the postoperative treatment of malignant gliomas. J Neurosurg 59: 106–110

    Article  PubMed  CAS  Google Scholar 

  4. Albert FK, Forsting M, Sartor K, Kunze S (1991) Frühes postoperatives CT und MR (-1+KM) nach Exstirpation von High grade-Gliomen — Erste Ergebnisse einer prospektiven Studie. In: Fimhaber W, Dworschak K, Lauer K, Nichtweiß M (eds) Multiple Sklerose. Neuroonkologie. Konstitutionelle Dyslexie. Springer, Berlin, Heidelberg, New York (Verhandlungen der Deutschen Gesellschaft für Neurologie, vol 6 ), pp 284–287

    Google Scholar 

  5. Anderson NR, Tandon DS (1991) Ifosfamide extrapyramidal neurotoxicity. Cancer 68: 72–75

    Article  PubMed  CAS  Google Scholar 

  6. Ausman JI, Levin VA, Brown WE, Rall DP, Fenstermacher JD (1977) Brain-tumor chemotherapy —pharmacological principles derived from a monkey brain-tumor model. J Neurosurg 46: 155–164

    Article  PubMed  CAS  Google Scholar 

  7. Baker WJ, Royer GLJ, Weiss RB (1991) Cytarabine and neurologic toxicity. J Clin Oncol 9: 679–693

    PubMed  CAS  Google Scholar 

  8. Bamberg M, Budach V, Stuschke M, Gerhard L (1988) Preliminary experimental results with the nitrosourea derivate ACNU in the treatment of malignant gliomas. Radiother Oncol 12: 25–29

    Article  PubMed  CAS  Google Scholar 

  9. Boethius J, Blomgren H, Collins VP, Greitz T, Strander H (1983) The effect of systemic human interferon-alpha administration to patients with glioblastoma multiforme. Acta Neurochir (Vienna) 68: 239–251

    Article  CAS  Google Scholar 

  10. Butti G, Knerich R, Tanghetti B, Adinolfi D, Gaetani P, Buoncristiani P, Paoletti P (1984) Perioperative carmustine chemotherapy for malignant brain tumors. Cancer Treat Rep 68: 1505–1506

    PubMed  CAS  Google Scholar 

  11. Cemy T, Meier C (1989) Neurotoxicity with cytostatic therapy:a review. Schweiz Med Wochenschr 119: 1137–1147

    Google Scholar 

  12. Djerassi I, Kim JS, Regev A (1985) Response of astrocytoma to high-dose methotrexate with citrovorum factor rescue. Cancer 55: 2741–2747

    Article  PubMed  CAS  Google Scholar 

  13. Duff TA, Bordon E, Bay J, Phepmeier J, Sielaff K (1986) Phase II trial for treatment of recurrent glioblastoma multiforme. J Neurosurg 64: 408–413

    Article  PubMed  CAS  Google Scholar 

  14. Eagan RT, Creagan ET, Bisel HF, Layton DD Jr, Groover RV, Hermann RC Jr (1981) Phase-IIStudies of dianhydrogalactidol-based combination chemotherapy for recurrent brain tumors. Oncology 38: 4–6

    Article  PubMed  CAS  Google Scholar 

  15. EORTC Brain Tumor Group (1978) Effect of CCNU on survival rate of objective remission and duration of free interval in patients with malignant brain glioma — final evaluation. Eur J Cancer 14: 851–855

    Article  Google Scholar 

  16. EORTC Brain Tumor Group (1981) Evaluation of CCNU, VM-26 plus CCNU and procarbazine in supratentorial brain gliomas. J Neurosurg 55: 27–31

    Article  Google Scholar 

  17. Forman A (1990) Recent studies on neurotoxicity and on the epidemiology of brain and nervous system tumors. Curr Opin Oncol 2: 691–698

    PubMed  CAS  Google Scholar 

  18. Forsting M, Albert FK, Kunze S, Sartor K (1992) Residual tumor after brain tumor resection? How to cut the Gordian knot with early postoperative MRI. Cancer Res Clin Oncol 118 [Suppl]: R106 (Abstract)

    Google Scholar 

  19. Goebel WE, Trappe AE, Weinzierl FX (1987) Perioperative cytostatische Behandlung supratentorieller maligner Hirntumoren mit BCNU unter spezieller Berücksichtigung der Tumorlage. Neurochirurgia 30: 82–87

    PubMed  CAS  Google Scholar 

  20. Green SB, Byar DP, Strike TA, Alexander E Jr, Brooks WH, Burger PC, Hunt WE, Mealey J Jr, Odom GL, Paoletti P, Pistenmaa DA, Ransohoff J II, Robertson JT, Selker RG, Shapiro WR, Smith KR Jr (1984) Randomized comparisons of BCNU, streptozotocin, radiosensitizer and fractionation of radiotherapy in the postoperative treatment of malignant glioma (study 7702). ASCO Proc 3: 230

    Google Scholar 

  21. Green SB, Byar DP, Strike TA, Burger PC, Mahaley MS Jr, Mealey J Jr, Pistenmaa DA, Ransohoff J, Robertson JT, Selker RG, Shapiro WR, van Gilder JC (1985) Randomized phase II comparison of PCNU and AZQ for the treatment of primary brain tumor (study 8120) ( BTSG Behtesda ). ASCO Proc 4: 143

    Google Scholar 

  22. Green SB, Byar DP, Walker MD, Pistenmaa DA, Alexander E Jr, Batzdorf U, Brooks WH, Hunt WE, Mealey J Jr, Odom GL, Paoletti P, Ransohoff J II, Robertson JT, Selker RG, Shapiro WR, Smith KR Jr (1983) Comparisons of carmustine, procarbazine and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer Treat Rep 67: 123–132

    Google Scholar 

  23. Haid M, Kandekhar JD, Merrill JM, Johnson CM, Locker GY, Blough R (1987) Phase II AZQ therapy for recurrent or progressive glioma of the central nervous system — final report. ASCO Proc 6: 266

    Google Scholar 

  24. Harmers FP, Gispen WH, Neijt JP (1991) Neurotoxic side-effects of cisplatin. Eur J Cancer 27: 372–376

    Article  PubMed  CAS  Google Scholar 

  25. Hatlevoll R, Lindegaard K-F, Hagen S, Kristiansen K, Nesbakken R, Torvik A, Ganz JC, Melia O, Rosengren B, Ringkjöb R, Arnasson O, Lindgren S, Lipecki M, Notter G, Littbrand B, Säterborg N-E, Benediktsson G, Johansson L, Spännare B, Brun A, Berthelsen A, Busch H, Grönbaek E, Rygard J, Haase JP, Lambrethsen E, Midholm S, Sehested P, Heikkinen M, Nyström S, Taskinen P, Mäntylä M, Elgen K, Aaskoven O, Gads de ST, Jensen RH, Matheson I (1985) Combined modality treatment of operated astrocytomas grade 3 and 4. Cancer 56: 41–47

    Article  PubMed  CAS  Google Scholar 

  26. Hildebrand J (1987) Chemotherapy of malignant supratentorial gliomas in adults: a ten year experience of the EORTC brain tumor group. In: Voth D, Krauseneck P (eds) Chemotherapy of gliomas. De Gruyter, Berlin

    Google Scholar 

  27. Hobert U, Krauseneck P, Bogdahn U, Neudecker T (1985) Phase I-II study of cytosine-arabinoside in malignant brain tumors. J Neurol [Suppl[7: 232

    Google Scholar 

  28. Hook CC, Kimmel DW, Kvols LK, Scheithauer BW, Forsyth PA, Rubin J, Moertel CG, Rodriguez M (1992) Multifocal inflammatory leukencephalopathy with 5-fluorouracil and levamisole. Ann Neurol 31: 262–267

    Article  PubMed  CAS  Google Scholar 

  29. Jellinger K, Kothbauer P, Volc D, Vollmer R, Weiss R (1979) Combination chemotherapy ( COMP protocol) and radiotherapy of anaplastic supratentorial gliomas. Acta Neurochir 51: 1–13

    Google Scholar 

  30. Kaplan RS, Wiemik PH (1984) Neurotoxicity of antitumor agents. In: Perry MC (ed) Toxicity of chemotherapy. Grune and Stratton, London, pp 365–433

    Google Scholar 

  31. Kornblith PL, Walker M (1988) Chemotherapy for malignant gliomas. J Neurosurg 68: 1–17

    Article  PubMed  CAS  Google Scholar 

  32. Krauseneck P, Dommasch D (1987) Zytostatische Therapie in der Neurologie. In: Flügel KA (ed) Neurologische and psychiatrische Therapie. Perimed, Erlangen, pp 363–378

    Google Scholar 

  33. Krauseneck P, Mertens H-G (1987) Results of chemotherapy of malignant brain tumors in adults. In: Jellinger K (ed) Therapy of malignant brain tumors. Springer, Vienna New York, pp 349–395

    Google Scholar 

  34. Krauseneck P, Mertens H-G, Messerer D, Kleihues P, Bamberg M, Dittmann W, Gerhard L, Heuser K, Müller B, Makoski HB, Ransmayr G, Richter E, Schröter C, Volc D, Wiehler S (1989) Zwischenergebnissse der deutsch-österreichischen Studie zu den malignen supratentoriellen Gliomen des Erwachsenenalters. In: Fischer P-A, Baas H, Enzensberger W (eds) Gerontoneurologie, Enzephalitiden, Neurogenetik. Springer, Berlin Heidelberg New York (Verhandlungen der Deutschen Gesellschaft für Neurologie, vol 5 ), pp 1090–1093

    Google Scholar 

  35. Levin VA, Silver P, Hannigan J, Wara WM, Gutin PH, Davis RL, Wilson CB (1989) Superiority of postradiotherapy adjuvant chemotherapy with CCNU, procarbazine and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys 18: 321–324

    Google Scholar 

  36. Levin VA, Wara WM, Davis RL, Vestnys P, Resser KJ, Yatsko K, Nutik S, Gutin P, Wilson CB (1985) Phase III comparison of BCNU and the combination of procarbazine, CCNU and vincristine administered after radiotherapy with hydroxyurea for malignant gliomas. J Neurosurg 63: 218–223

    Google Scholar 

  37. Levin VA, Wilson CB, Davis R, Wara WM, Pischer TL, Irwin L (1979) A phase III comparison of BCNU hydroxyurea and radiation therapy to BCNU and radiation therapy for treatment of primary malignant gliomas. J Neurosurg 51: 526–532

    Article  PubMed  CAS  Google Scholar 

  38. Lieberman AN, Foo SH, Ransohoff J, Wise A, George A, Gordon W, Walker R (1982) Long term survival among patients with malignant brain tumors. Neurosurgery 10: 450–453

    Article  PubMed  CAS  Google Scholar 

  39. Mahaley MS Jr (1991) Neuro-oncology index and review (adult primary brain tumors). J Neurooncol 11: 85–147

    Article  PubMed  Google Scholar 

  40. Mahaley MSJ, Hipp SW, Dropcho EJ, Bertsch L, Cush S, Tirey T, Gillespie GY (1989) Intracarotid cisplatin chemotherapy for recurrent gliomas. J Neurosurg 70: 371–378

    Article  PubMed  Google Scholar 

  41. Merimsky O, Reider Groswasser I, Inbar M, Chaitchik S (1990) Interferon-related mental deterioration and behavioral changes in patients with renal cell carcinoma. Eur J Cancer 26: 596–600

    Article  PubMed  CAS  Google Scholar 

  42. Mertens H-G (1982) Postoperative Strahlen-and Chemotherapie mit BCNU and VM26 bei malignen supratentoriellen Gliomen des Erwachsenenalters. Protokoll der multizentrischen Therapiestudie der deutschen Himtumorgruppe

    Google Scholar 

  43. Nagai M, Arai T (1984) Clinical effect of interferon in malignant brain tumors. Neurosurg Rev 7: 55–64

    Article  PubMed  CAS  Google Scholar 

  44. Paoletti P, Knerich R, Butti G, Adinolfi D, Locatelli D, Robustelli della Cuna G, Cordero di Montezemolo L, Schiffer D, Soffietti R, Nicolato A, Giunta F, Buoncristiani P, Scamoni C (1983) Italian cooperative study on malignant glial tumor therapy. In: Krauseneck P, Mertens H-G (eds) Therapie maligner Neoplasien des Gehirns. Perimed, Erlangen

    Google Scholar 

  45. Potthoff PC (1981) Ergebnisse der Therapie maligner Hirntumoren. In: Potthoff PC, Schreml W (eds) Maligne Hirntumoren. Huber, Bern

    Google Scholar 

  46. Pouillart P, Mathe G, Thy T (1976) Treatment of malignant gliomas and brain metastasis in adults with a combination of adriamycin, VM26 and CCNU. Cancer 38: 1909–1916

    Article  PubMed  CAS  Google Scholar 

  47. Rozenthal JM, Robins HI, Finlay JL, Healey B, Levin AB, Steeves RA, Kohler PC, Schutta HS, Trump DL (1989) Eight-drugs-in-one-day chemotherapy in postirradiated adult patients with malignant gliomas. Med Pediatr Oncol 17: 471–476

    Article  Google Scholar 

  48. Shapiro WR (1986) Therapy of adult malignant brain tumors: what have the clinical trials taught us? Semin Oncol 13: 38–4

    PubMed  CAS  Google Scholar 

  49. Shapiro WR, Green SB, Burger PC, Mahaley MS Jr, Selker RG, van Gilder JC, Robertson JT, Ransohoff J, Mealey J Jr, Strike TA et al (1989) Randomized trial of three chemotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001. J Neurosurg 71: 1–9

    Article  PubMed  CAS  Google Scholar 

  50. Shapiro WR, Green SB, Burger PC, Selker RG, van Gilder JC, Robertson JT, Mealey J Jr, Ransohoff J, Mahaley MS Jr (1987) A randomized comparison of intraarterial vs intravenous BCNU for patients with malignant glioma (study 8301): interim analysis demonstrating lack of efficacy for is BCNU. ASCO Proc 6: 268

    Google Scholar 

  51. Shapiro WR, Young DF (1976) Treatment of malignant glioma. Arch Neurol 33: 494–500

    Article  PubMed  CAS  Google Scholar 

  52. Shapiro WR, Young DF (1984) Neurological complications of antineoplastic therapy. Acta Neurol Scand 70 [Suppl 100]: 125–132

    Google Scholar 

  53. Shibata S, Mori K, Moriyama T, Tanaka K, Moroki J (1987) Randomized controlled study of the effect of adjuvant immunotherapy with Picibanil on 51 malignant gliomas. Surg Neurol 27: 259–263

    Article  PubMed  CAS  Google Scholar 

  54. Taylor S, Eyre HJ (1987) Randomized phase II trials of acivicin and fludarabine in recurrent malignant gliomas: a SWOG study. ASCO Proc 6: 71

    Google Scholar 

  55. Thomas DGT, Darling JL, Paul EA, Mott TJ, Godlee JN, Tobias JS, Capra LG, Collins CD, Mooney C, Bozek T, Finn GP, Aribabu SO, Bullard DE, Shannon N, Freshney RI (1985) Assay of anti-cancer drugs in tissue culture: relationship of relapse free interval ( RFI) and in vitro chemosensitivity in patients with malignant cerebral glioma. Br J Cancer 51: 525–532

    Google Scholar 

  56. Tirelli U, D’Incalci M, Canetta R, Tumolo S, Franchin G, Veronesi A, Galligioni E, Trovo MG, Rossi C, Grigoletto E (1984) Etoposide in malignant brain tumors: a phase II study. J CI in Oncol 2: 432–437

    CAS  Google Scholar 

  57. Trojanowski T, Peszynski J, Turowski K, Markiewicz P, Goscinski I, Bielawski A, Bendarzewska B, Szymona J, Dabrowska A, Lopatkiewicz J et al (1989) Quality of survival of patients with brain gliomas treated with postoperative CCNU and radiation therapy. J Neurosurg 70: 18–23

    Article  PubMed  CAS  Google Scholar 

  58. Ushio Y, Abe H, Suzuki J, Tanaka R, Kitamura K, Miwa T, Matsutani M, Takeuchi K, Takakura K, Nomura K et al (1985) Evaluation of ACNU alone and combined with tegafur as additions to radiotherapy of the treatment of malignant gliomas — a cooperative clinical trial. No To Shinkei 37: 999–1006

    PubMed  CAS  Google Scholar 

  59. Voth D, Hüwel N, Al-Hami S, Kühnert A (1984) Mono-treatment of malignant glioma with a derivate of nitrosourea ACNU (first results). In: Voth D, Krauseneck P (eds) Chemotherapy of gliomas. de Gruyter, Berlin, pp 361–372

    Google Scholar 

  60. Walker MD, Alexander E Jr, Hunt WE, MacCarty CS, Mahaley MS Jr, Mealey J Jr, Nowell HA, Ransohoff J, Wilson CB, Gehan EA, Strike TA (1978) Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. J Neurosurg 49: 333–343

    Article  PubMed  CAS  Google Scholar 

  61. Walker MD, Green SB, Byar DP, Alexander E Jr, Batzdorf U, Brooks WH, Hunt WE, MacCarty CS, Mahaley MS Jr, Mealey J Jr, Owens G, Ransohoff J II, Robertson JT, Shapiro WR, Smith KR Jr, Wilson CB, Strike TA (1980) Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303: 1323–1329

    Article  PubMed  CAS  Google Scholar 

  62. Yamashima T, Yamashita J, Shoin K (1990) Neurotoxicity of local administration of two nitrosoureas in malignant gliomas. Neurosurgery 26: 794–799

    Article  PubMed  CAS  Google Scholar 

  63. Zimm S, Ettinger LJ, Holgenberg SJ et al (1985) Phase I and clinical pharmacological study of mercaptopurine administered as a prolonged intravenous infusion. Cancer Res 45: 1869–1873

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Neurologische Klinik, St-Getreu-Str. 14–18, 96049, Bamberg, Germany

    P. Krauseneck

  2. Kopfklinikum Würzburg, Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080, Würzburg, Germany

    B. Müller

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  1. P. Krauseneck
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Editors and Affiliations

  1. Institut für Neuropathologie, Universitätskliniken Bonn, Sigmund-Freud-Straße 25, 53105, Bonn, Germany

    O. D. Wiestler

  2. Neurologische Universitätsklinik, Sigmund-Freud-Straße 25, 53105, Bonn, Germany

    U. Schlegel  & J. Schramm  & 

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© 1994 Springer-Verlag Berlin Heidelberg

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Krauseneck, P., Müller, B. (1994). Chemotherapy of Malignant Gliomas. In: Wiestler, O.D., Schlegel, U., Schramm, J. (eds) Molecular Neuro-oncology and Its Impact on the Clinical Management of Brain Tumors. Recent Results in Cancer Research, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85039-4_14

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  • DOI: https://doi.org/10.1007/978-3-642-85039-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85041-7

  • Online ISBN: 978-3-642-85039-4

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