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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 135))

Abstract

Aggressive oligodendrogliomas, tumors that are symptomatic, enlarging, enhancing, and usually but not always anaplastic (Fig. 1), respond to chemotherapy. PCV, a regimen that includes procarbazine, lomustine (CCNU), and vincristine, is predictably effective, but other drugs have anti-oligodendroglioma activity. Cooperative group trials will be necessary to determine the most effective drug or drug combination and to explore fully the role of chemotherapy in the treatment of this uncommon glioma.

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References

  1. Bishop M, de la Monte SM (1989) Dual lineage of astrocytomas. Am J Pathol 135: 517–527

    CAS  Google Scholar 

  2. Brown M, Caimcross JG, Vick NA, Macdonald DR, Friedman HS, Dropcho EJ, Schold SC Jr (1990) Differential response of recurrent oligodendrogliomas versus astrocytomas to intravenous melphalan. Neurology 40 [Suppl 1]: 397–398 (abstr)

    Google Scholar 

  3. Cairncross JG, Laperriere NJ (1989) Low-grade glioma:to treat or not to treat? Arch Neurol 46: 1238–1239

    Article  PubMed  CAS  Google Scholar 

  4. Cairncross JG, Macdonald DR (1988) Successful chemotherapy for recurrent malignant oligodendroglioma. Ann Neurol 23: 460–464

    Article  Google Scholar 

  5. Cairncross JG, Macdonald DR (1991) Chemotherapy for oligodendroglioma – progress report. Arch Neurol 48: 226–227

    Google Scholar 

  6. de la Monte SM (1989) Uniform lineage of oligodendrogliomas. Am J Pathol 135: 529–540

    PubMed  Google Scholar 

  7. Frosina G, Rossi O, Arena G, Gentile SL, Bruzzone E, Abbondandolo A (1990) O6 Alkylguanine–DNA alkyltransferase activity in human brain tumors. Cancer Lett 55: 153–158

    Article  PubMed  CAS  Google Scholar 

  8. Glass J, Hochberg FH, Gruber ML, Louis DN, Smith D, Rattner B (1992) The treatment of oligodendrogliomas and mixed oligodendroglioma — astrocytoma with PCV chemotherapy. J Neurosurg 76: 741–745

    Article  PubMed  CAS  Google Scholar 

  9. Green SB, Byar DP, Walker MD, Pistenmaa DA, Alexander E Jr, Batzdorf U, Brooks WH, Hunt WE, Mealey J Jr, Odom GL, Paoletti P, Ransohoff J, Robertson JT, Selker RG, Shapiro WR, Smith KR, Wilson CB, Strike TA (1983) Comparisons of carmustine, procarbazine, and high-dose methyl prednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer Treat Rep 67: 121–132

    PubMed  CAS  Google Scholar 

  10. Gutin PH, Leibel SA, Wara WM, Choucair A, Levin VA, Philips TL, Silver P, DaSilva V, Edwards MS, Davis RL, Weaver KA, Lamb S (1987) Recurrent malignant gliomas:survival following interstitial brachytherapy with high-activity iodine-125 sources. J Neurosurg 67: 864–871

    Article  PubMed  CAS  Google Scholar 

  11. Hoshino T, Rodriguez LA, Cho KG, Lee KS, Wilson CB, Edwards MSB, Levin VA, Davis RL (1988) Prognostic implications of the proliferative potential of low-grade astrocytomas. J Neurosurg 69: 839–842

    Article  PubMed  CAS  Google Scholar 

  12. Kleihues P, Sarioglu A, Shibata T, Yasargil GM (1989) Ki-67 expression in the multiform glioblastoma:correlation between growth fraction and patient survival. Clin Neuropath 8: 206 (abstr)

    Google Scholar 

  13. Komblith PL, Walker MD (1988) Chemotherapy for malignant gliomas. J Neurosurg 68: 1–17

    Article  Google Scholar 

  14. Levin VA, Edwards MS, Wright DC, Seager ML, Pischer-Schimberg T, Townsend JJ, Wilson CB (1980) Modified procarbazine, CCNU and vincristine (PCV-3) combination chemotherapy in the treatment of malignant brain tumors. Cancer Treat Rep 64: 237–241

    PubMed  CAS  Google Scholar 

  15. Levin VA, Silver P, Hannigan J, Wara WM, Gutin PH, Davis RL, Wilson CB (1990) Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas:NCOG 6G61 final report. Int J Rad Oncol Biol Phys 18: 321–324

    Article  CAS  Google Scholar 

  16. Longee DC, Friedman HS, Albright RE, Burger PC, Oakes WJ, Moore JO, Schold SC Jr (1990) Treatment of patients with recurrent gliomas with cyclophosphamide and vincristine. J Neurosurg 72: 583–588

    Article  PubMed  CAS  Google Scholar 

  17. Macdonald DR, Cascino TL, Schold Sc Jr, Cairncross JG (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 7: 1277–1280

    Google Scholar 

  18. Macdonald DR, Gaspar LE, Cairncross JG (1990) Successful chemotherapy for newly diagnosed aggressive oligodendroglioma. Ann Neurol 27: 573–574

    Article  PubMed  CAS  Google Scholar 

  19. Morimura T, Kitz K, Budka H (1989) Proliferation markers for human brain tumors. Clin Neuropath 8: 206 (abstr)

    Google Scholar 

  20. Poisson M, Chiras J, Fauchon F, Debussche C, Delattre JY (1990) Treatment of malignant recurrent glioma by intra-arterial, infra-ophthalmic infusion of HECNU 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl) urea. A phase II study. J Neuro-Oncol 8: 255262

    Google Scholar 

  21. Rubinstein LJ (1972) Tumors of the nervous system. Armed Forces Institute of Pathology, Washington, D.C. (Fascicle 6 )

    Google Scholar 

  22. Saarinen UM, Pihko H, Makipernaa A (1990) High-dose thiotepa with autologous bone marrow rescue in recurrent malignant oligodendroglioma:a case report. J Neuro-Oncol 9: 5762

    Article  Google Scholar 

  23. Schold SC Jr, Brent TP, von Hofe E, Friedman HS, Mitra S, Bigner D, Swenberg JA, Kleihues P. O6-Alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human braintumor xenografts. J Neurosurg 70: 573–577

    Google Scholar 

  24. Walker MD, Alexander E Jr, Hunt WE, MacClarty CS, Mahaley MS, Mealey J Jr, Norrell HA, Owens G, Ransohoff J, Wilson CB, Gehan EA, Strike TA (1978) Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg 49: 333–343

    Article  PubMed  CAS  Google Scholar 

  25. Walker MD, Green SB, Byar DP, Alexander E Jr, Batzdorf U, Brooks WH, Hunt WE, MacCarty CS, Mahaley MS, Mealey J Jr, Owens G, Ransohoff J, Robertson JT, Shapiro WR, Smith KR, Wilson CB, Strike TA (1980) Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303: 1323–1329

    Article  PubMed  CAS  Google Scholar 

  26. Wiestler O, Kleihues P, Pegg AE (1984) O6-Alkylguanine-DNA akyltransferase activity in human brain and brain tumors. Carcinogenesis 5: 121–124

    Article  PubMed  CAS  Google Scholar 

  27. Young B, Oldfield EH, Markesbery WR, Haack D, Tibbs PA, McCombs P, Chin HW, Maruyama Y, Meacham WR (1981) Re-operation for glioblastoma. J Neurosurg 55: 917–921

    Article  PubMed  CAS  Google Scholar 

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© 1994 Springer-Verlag Berlin Heidelberg

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Cairncross, J.G. (1994). Aggressive Oligodendroglioma: A Chemosensitive Tumor. In: Wiestler, O.D., Schlegel, U., Schramm, J. (eds) Molecular Neuro-oncology and Its Impact on the Clinical Management of Brain Tumors. Recent Results in Cancer Research, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85039-4_13

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  • DOI: https://doi.org/10.1007/978-3-642-85039-4_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85041-7

  • Online ISBN: 978-3-642-85039-4

  • eBook Packages: Springer Book Archive

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