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Sepsis pp 425-442 | Cite as

N-Acetylcysteine in Sepsis

  • C. Spies
  • K. Reinhart
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 18)

Abstract

Sepsis, septic shock and multiple organ dysfunction syndrome are characterized by progressive inadequate tissue perfusion and maldistribution of blood flow [1]. Endothelium-derived relaxing factor is considered to be important in maintaining nutrive blood flow [2]. Increased oxygen radicals known to be generated in large amounts during endotoxic shock and sepsis [3–8] inactivate nitric oxide or 5-nitrocysteine, which account for the vasodilator action of endothelium-derived relaxing factor [9–12]. A constitutive nitric oxide synthase is present in endothelial cells [9], certain neurons [3, 14], endocardium [15], myocardium [16] and platelets [17, 18].

Keywords

Nitric Oxide Septic Shock Multiple Organ Dysfunction Syndrome Adult Respiratory Distress Syndrome Septic Shock Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • C. Spies
  • K. Reinhart

There are no affiliations available

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