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Sepsis pp 397–413Cite as

Platelet-Activating Factor: Pathophysiological Changes and Therapeutic Implications in Sepsis

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Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 18))

Abstract

Platelet-activating factor (PAF) is a potent phospholipid autacoid implicated as mediator in diverse inflammatory pathologies [1–4] including the systemic inflammatory response to sepsis [5]. PAF has been identified as an important trigger of cell-to-cell interaction, leading to the release of other inflammatory mediators [1, 4]. This suggestion is based on a large body of evidence.

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Authors
  1. J.-F. Dhainaut
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  2. J.-P. Mira
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  3. L. Fiérobe
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Editors and Affiliations

  1. Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller-Universität Jena, Bachstraße 18, 07740, Jena, Germany

    Konrad Reinhart

  2. Klinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Steglitz der FU Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Klaus Eyrich

  3. Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University, Medical Center, P. O. Box 12000, 91120, Jerusalem, Israel

    Charles Sprung (Direktor) (Direktor)

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© 1994 Springer-Verlag Berlin Heidelberg

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Dhainaut, JF., Mira, JP., Fiérobe, L. (1994). Platelet-Activating Factor: Pathophysiological Changes and Therapeutic Implications in Sepsis. In: Reinhart, K., Eyrich, K., Sprung, C. (eds) Sepsis. Update in Intensive Care and Emergency Medicine, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85036-3_32

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  • DOI: https://doi.org/10.1007/978-3-642-85036-3_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85038-7

  • Online ISBN: 978-3-642-85036-3

  • eBook Packages: Springer Book Archive

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