Tumor Necrosis Factor-Neutralization with a Specific Monoclonal Antibody
Sepsis is a clinical condition which represents a systemic response to infection. It has been described for more than 40 years . In spite of significant advances in antimicrobial therapy, lethality of this disease is still high, and septic shock is still estimated to account for about 100000 deaths in the USA annually . During recent years the involvement of both humoral pathways and the cytokine network of the host and their interaction with cellular mechanisms in the induction of the clinical symptoms and consequences of sepsis have gained major scientific attention . The interruption of the endogenous inflammatory cascade has become a novel approach for the treatment of sepsis and septic shock .
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