Sepsis pp 228-238 | Cite as

Definitions and Therapy of Sepsis

  • R. C. Bone
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 18)


The syndrome of multiple systems organ failure (MSOF) is defined as the presence of two or more organ systems with impaired function. MSOF is characterized by a hyperdynamic, hypermetabolic state identical to that seen in the septic syndrome. The mortality rate associated with MSOF exceeds 60% and the emergence of MSOF and the septic syndrome as important clinical entities is related to improvements in the technology of life support systems.


Septic Shock Toxic Shock Syndrome Opiate Antagonist Capillary Leak Syndrome Multiple System Organ Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1994

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  • R. C. Bone

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