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Sepsis pp 228-238 | Cite as

Definitions and Therapy of Sepsis

  • R. C. Bone
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 18)

Abstract

The syndrome of multiple systems organ failure (MSOF) is defined as the presence of two or more organ systems with impaired function. MSOF is characterized by a hyperdynamic, hypermetabolic state identical to that seen in the septic syndrome. The mortality rate associated with MSOF exceeds 60% and the emergence of MSOF and the septic syndrome as important clinical entities is related to improvements in the technology of life support systems.

Keywords

Septic Shock Toxic Shock Syndrome Opiate Antagonist Capillary Leak Syndrome Multiple System Organ Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bone RC, Balk RA, Cerra FB et al (1992) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864–874CrossRefGoogle Scholar
  2. 2.
    Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA (1987) A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 317(11): 653–658PubMedCrossRefGoogle Scholar
  3. 3.
    Goris RJ, Nuytinck HK, Redl H (1987) Scoring systems and predictors of ARDS and MOF. Prog Clin Biol Res 236B:3–15PubMedGoogle Scholar
  4. 4.
    Jacobs ER, Bone RC (1983) Sepsis. In: Bone RC (ed) Pulmonary disease reviews, vol IV. Wiley, New York, pp 99–117Google Scholar
  5. 5.
    Jacobs ER, Bone RC (1986) Clinical indicators in sepsis and septic adult respiratory distress syndrome. Med Clin North Am 70(4): 921–932PubMedGoogle Scholar
  6. 6.
    Schuster HP (1987) Multisystem organ failure. Prog Clin Biol Res 236A: 459–462PubMedGoogle Scholar
  7. 7.
    Schwartz DB, Bone RC, Balk RA, Szidon JP (1989) Hepatic dysfunction in the adult respiratory distress syndrome. Chest 95(4): 871–875PubMedCrossRefGoogle Scholar
  8. 8.
    Tracey KJ, Lowry SM, Cerami A (1988) Cachetin/TNF-alpha in septic shock and septic adult respiratory distress syndrome. Am Rev Respir Dis 138(6): 1377–1379PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • R. C. Bone

There are no affiliations available

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