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Metabolic Responses to Anti-Cytokine Therapies

  • Chapter
Metabolic Support of the Critically Ill Patient

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 17))

Abstract

Severe injury or invasive infection induce complex alterations of host metabolic and immunologic function. Although it is evident that these are dynamic processes serving as necessary adjuncts to the normal evolution of repair, their propagation may become severely dysfunctional in the setting of complicated injury or organ failure. Despite the clinical application of advanced technology for anti-microbial therapy, organ support, and nutrition, the mechanisms underlying the evolution of such adverse events have generally proven elusive. This discussion will selectively review current understanding of the potential role for inflammatory mediators as proximal determinants of the acute and chronic host metabolic responses to injury or infection. Where possible, observations derived from human systems will be utilized and, additionally, data suggesting the potential influence of anti-cytokine therapies upon these events will be provided.

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Authors
  1. S. F. Lowry
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Editor information

Editors and Affiliations

  1. Laboratory for Surgical Metabolism, Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachussetts, 02115, USA

    Douglas W. Wilmore

  2. L. Deloyers Laboratory for Experimental Surgery, Free University of Brussels, Avenue J. Wybran 40, 1070, Brussels, Belgium

    Yvon A. Carpentier

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© 1993 Springer-Verlag Berlin Heidelberg

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Lowry, S.F. (1993). Metabolic Responses to Anti-Cytokine Therapies. In: Wilmore, D.W., Carpentier, Y.A. (eds) Metabolic Support of the Critically Ill Patient. Update in Intensive Care and Emergency Medicine, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85011-0_19

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  • DOI: https://doi.org/10.1007/978-3-642-85011-0_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85013-4

  • Online ISBN: 978-3-642-85011-0

  • eBook Packages: Springer Book Archive

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