Metabolic Responses to Anti-Cytokine Therapies
Severe injury or invasive infection induce complex alterations of host metabolic and immunologic function. Although it is evident that these are dynamic processes serving as necessary adjuncts to the normal evolution of repair, their propagation may become severely dysfunctional in the setting of complicated injury or organ failure. Despite the clinical application of advanced technology for anti-microbial therapy, organ support, and nutrition, the mechanisms underlying the evolution of such adverse events have generally proven elusive. This discussion will selectively review current understanding of the potential role for inflammatory mediators as proximal determinants of the acute and chronic host metabolic responses to injury or infection. Where possible, observations derived from human systems will be utilized and, additionally, data suggesting the potential influence of anti-cytokine therapies upon these events will be provided.
KeywordsMetabolic Response Mediator System Tumor Necrosis Factor Production Counterregulatory Hormone Neuroendocrine Hormone
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