Distinctive Chemoanatomical and Developmental Features of the Prefrontal Dopaminergic System in Primates as Compared to Rodents
Phylogenetic considerations of the dopaminergic (DA) innervation of the prefrontal cortex illustrate the pitfalls of extrapolating data obtained in rodent brain to human or nonhuman primates, as has been the case for about 15 years. Comparative studies of prefrontal DA innervation in rats and primates are complicated by several features; including the lack in rodents of a frontal area strictly homologous to the primate prefrontal cortex, the heterogeneity of the dopaminergic population which provides the cortical projections in rats, and the major evolutionary changes of the cortical DA innervation in primates. The main distinctive features between rats and primates with respect to prefrontal DA innervation are reviewed in this paper, and the value of the rat as a representative model for that study is further discussed.
KeywordsDopamine Schizophrenia Neurol Catecholamine Clozapine
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