Distinctive Chemoanatomical and Developmental Features of the Prefrontal Dopaminergic System in Primates as Compared to Rodents

  • B. Berger
Conference paper
Part of the Research and Perspectives in Neurosciences book series (NEUROSCIENCE)


Phylogenetic considerations of the dopaminergic (DA) innervation of the prefrontal cortex illustrate the pitfalls of extrapolating data obtained in rodent brain to human or nonhuman primates, as has been the case for about 15 years. Comparative studies of prefrontal DA innervation in rats and primates are complicated by several features; including the lack in rodents of a frontal area strictly homologous to the primate prefrontal cortex, the heterogeneity of the dopaminergic population which provides the cortical projections in rats, and the major evolutionary changes of the cortical DA innervation in primates. The main distinctive features between rats and primates with respect to prefrontal DA innervation are reviewed in this paper, and the value of the rat as a representative model for that study is further discussed.


Prefrontal Cortex Tyrosine Hydroxylase Anterior Cingulate Cortex Ventral Tegmental Area Ventral Mesencephalon 
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© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • B. Berger
    • 1
  1. 1.INSERM U106, Bâtiment de PédiatrieHôpital SalpêtrièreParis Cedex 13France

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