The Herpes Simplex Type 1 Virus Latency Gene
The ability of herpesviruses to establish, maintain, and reactivate from latent infections is a hallmark of the group. Latent phase gene expression is under different control than is herpesvirus lytic phase infection. Recent experimental analysis of herpes simplex virus latency indicates that the latent phase is characterized by the expression of a single transcript unit (the latency-associated transcription unit, LAT). Transcripts expressed from this LAT are complexly processed to yield a stable intron and a number of, as yet, not fully characterized polyadenylated forms. One or more of these processed transcripts play an important role in the reactivation process, but the biological mechanism underlying this role is not understood.
KeywordsHerpes Simplex Virus Type Trigeminal Ganglion Latent Infection Infected Neuron Lytic Phase
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