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Induction Chemotherapy for Organ Preservation in Advanced Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

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Carcinoma of the Oral Cavity and Oropharynx

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 134))

Abstract

Squamous carcinoma of the upper aerodigestive tract comprises 5% of new cancer cases each year and accounts for 12000–15000 deaths. It is estimated that over 30000 new cases of oral cavity and pharynx cancer occur each year (Silverberg et al. 1990). Two thirds of these will be advanced (stage III or IV) at time of diagnosis. Conventional treatment strategies for these patients consist of combinations of radical surgical resection and postoperative radiation therapy and are associated with dismal 3-year survival rates ranging from 0%–50%. Furthermore, these treatment approaches result in significant functional and cosmetic disabilities due to radical resections of the tongue, mandible, pharynx, and larynx. Despite continuing refinements in surgical reconstruction, cancers arising in the oral cavity and pharynx consistently result in significant impairments in speech and swallowing that seriously affect quality of life.

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Author information

Authors and Affiliations

  1. Department of Otolaryngology — Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA

    G. T. Wolf

  2. Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA

    S. Urba

  3. Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI, 48109, USA

    M. Hazuka

Authors
  1. G. T. Wolf
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  2. S. Urba
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  3. M. Hazuka
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Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Zahn-, Mund- und Kieferheilkunde, Mund-, Kiefer- und Gesichtschirurgie, Joseph-Stelzmann-Str. 9, 50931, Köln, Germany

    H.-D. Pape

  2. Hals-, Nasen- und Ohrenklinik, Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany

    U. Ganzer

  3. Klinik fur Strahlentherapie, Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany

    G. Schmitt

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© 1994 Springer-Verlag Berlin Heidelberg

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Wolf, G.T., Urba, S., Hazuka, M. (1994). Induction Chemotherapy for Organ Preservation in Advanced Squamous Cell Carcinoma of the Oral Cavity and Oropharynx. In: Pape, HD., Ganzer, U., Schmitt, G. (eds) Carcinoma of the Oral Cavity and Oropharynx. Recent Results in Cancer Research, vol 134. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84971-8_15

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  • DOI: https://doi.org/10.1007/978-3-642-84971-8_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84973-2

  • Online ISBN: 978-3-642-84971-8

  • eBook Packages: Springer Book Archive

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