Abstract
Adenosine monophosphate (AMP) deaminase is a purine nucleotide interconverting enzymatic activity critical to energy metabolism, e.g., its role in the proposed functions of the purine nucleotide cycle (Lowenstein 1972). In higher eukaryotes, multiple isoforms exhibiting tissue-specific and developmental patterns of expression have been described. In addition to exhibiting diverse biochemical and immunological properties, limited cellular biology studies suggest that intraspecies variants of AMP deaminase occupy different intracellular addresses. Recent molecular studies have demonstrated AMP deaminase isoforms to be manifest through the expression of a multigene family, some members of which produce primary transcripts subject to alternative splicing. Clinically, inherited and acquired deficiencies of skeletal muscle AMP deaminase (Sabina et al. 1989b) and an inherited deficiency in erythrocytes (Ogasawara et al. 1984b) have been described. Our laboratory is utilizing cellular and molecular approaches to gain insight into the functional significance of AMP deaminase isoform diversity.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ashby B, Holmsen H (1981) Platelet AMP deaminase: Purification and kinetic studies. J Biol Chem 256: 10519–10523
Benders AAGM, van Kuppevelt THMSM, Oosterhof A, Veerkamp JH (1991) The biochemical and structural maturation of human skeletal muscle cells in culture: The effect of the serum substitute Ultroser G. Exper Cell Res 195: 284–294
Chang Z, Nygaard P, Chinault AC, Kellems RE (1991) Deduced amino acid sequence of Escherichia coli adenosine deaminase reveals evolutionarily conserved amino acid residues: Implications for catalytic function. Biochemistry USA 30: 2273–2280
Coffee CJ, Kofke WA (1975) Rat muscle 5’-adenylic acid aminohydrolase. I. Purification and subunit structure. J Biol Chem 250: 6653–6658
Cserjesi P, Olson EN (1991) Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products, Mol Cell Biol 11: 4854–4862
Fishbein WN, Griffin JL, Armbrustmacher VW (1980) Stain for skeletal muscle adenylate deaminase: An effective terazolium stain for frozen biopsy specimens. Arch Pathol Lab Med 104: 462–466
Gilloteaux J, Meyer RA (1983) AMP deaminase histoenzymatic staining in rat intrafusal muscle fibers and other skeletal muscle tissues. Z Mikrosk-Anat Forsch 97: S705–S712
Kaletha K, Skladanowski A (1979) Regulatory properties of rat heart AMP deaminase. Biochim Biophys Acta 568: 80–90
Kaletha K, Spychala J, Nowak G (1987) Developmental forms of human skeletal muscle AMP-deaminase. Experientia 43: 440–443 Kaletha K, Nowak G (1988) Developmental forms of human skeletal-muscle AMP deaminase: The kinetic and regulatory properties of the enzyme. Biochem J 249: 255–261
Lowenstein JM (1972) Ammonia production in muscle and other tissues: The purine nucleotide cycle. Physical Rev 52: 382–414
Marquetant R, Desai NM, Sabina RL, Holmes EW(1987) Evidence for sequential expression of multiple AMP deaminase isoforms during skeletal muscle development. Proc Natl Acad Sci USA 84: 2345–2349
Marquetant R, Sabina RL, Holmes EW (1989) Identification of a noncatalytic domain in AMP deaminase that influences binding to myosin. Biochemistry USA 28: 8744–8749
Meyer RA, Gilloteaux J, Terjung RL (1980) Histochemical differences in AMP deaminase activity in rat skeletal muscle-fibres. Experientia 36: 676–677
Meyer SL, Kvalnes-Krick KL, Schramm VL (1989) Characterization of AMD, the AMP deaminase gene in yeast. Production of amd strain, cloning, nucleotide sequence, and properties of the protein. Biochemistry USA 28: 8734–8743
Mineo I, Clarke PRH, Sabina RL, Holmes EW (1990) A novel pathway for alternative splicing: Identification of an RNA intermediate that generates an alternative 5’ splice donor site not present in the primary transcript of AMPD1. Mol Cell Biol 10: 5271–5278
Mineo I, Holmes EW (1991) Exon recognition and nucleocytoplasmic partitioning determine AMPD1 alternative transcript production. Mol Cell Biol 11: 5356–5363
Morisaki T, Sabina RL, Holmes EW (1990) Adenylate deaminase: A multigene family in humans and rats. J Biol Chem 265: 11482–11486
Morisaki T, Sabina RL, Holmes EW (1991a) A unique muscle-specific enhancer in the AMPD1 gene. J Cell Biochem 15C(Suppl): 77 Morisaki T, Gross M, Morisaki H, Holmes E (1991b) A single mutant allele accounts for the high frequency of AMP deaminase deficiency in Caucasians. Clin Res 39: 377A
Ogasawara N, Goto H, Watanabe T (1975a) Isozymes of rat AMP deaminase. Biochim Biophys Acta 403: 530–537
Ogasawara N, Goto H, Watanabe T (1975b) Isozymes of rat brain AMP deaminase: Developmental changes and characterization of five forms. FEBS Lett 58: 245–248
Ogasawara N, Goto H, Yamada Y, Yoshino M (1977) Subunit structures of AMP deaminase isozymes in rat. Biochem Biophys Res Comm 79: 671–676
Ogasawara N, Goto H, Yamada Y, Watanabe T(1978a) Distribution of AMP-deaminase isozymes in rat tissues. Eur J Biochem 87: 297–304
Ogasawara N, Goto H, Yamada Y(1978b) Effects of various ligands on interaction of AMP deaminase with myosin. Biochim Biophys Acta 524: 442–446
Ogasawara N, Goto H, Yamada Y (1979) Regulatory properties of AMP deaminase isozymes. In: Rapado A, Watts RWE, deBruyn CHMM (eds) Purine metabolism in man- Ill. Plenum, New York, pp 169–175
Ogasawara N, Goto H, Yamada Y, Watanabe T, Asano T (1982) AMP deaminase isozyme in human tissues. Biochim Biophys Acta 714: 298–306
Ogasawara N, Goto H, Yamada Y, Watanabe T(1984a) Distribution of AMP deaminase isozymes in various human blood cells. Int J Biochem 16: 269–273
Ogasawara N, Goto H, Yamada Y, Nishigaki I, Itoh T, Hasegawa I (1984b) Complete deficiency of AMP deaminase in human erythrocytes. Biochem Biophys Res Comm 122: 1344–1349
Pipoly GM, Nathans GR, Chang D, DeuelTF (1979) Regulation of the interaction of purified human erythrocyte AMP deaminase and the human erythrocyte membrane. J Clin Invest 63: 1066–1067
Rao N, Hara L, Askari A (1968) Alkali cation-activated AMP deaminase of erythrocytes: Properties of the membrane-bound enzyme. Biochim Biophys Acta 151: 651–654
Sabina RL, Marquetant R, Desai NM, Kaletha K, Holmes EW (1987) Cloning and sequence of rat myoadenylate deaminase cDNA: Evidence for tissue-specific and developmental regulation. J Biol Chem 262: 12397–12400
Sabina RL, Swain JL, Holmes EW (1989a) Myoadenylate deaminase deficiency. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic basis of inherited disease. McGraw-Hill, New York, pp 1077–1084
Sabina RL, Ogasawara N, Holmes EW (1989b) Expression of three stage-specific transcripts of AMP deaminase during myogenesis. Mol Cell Biol 9: 2244–2246
Sabina RL, Morisaki T, Clarke P, Eddy R, Shows TB, Morton CC, Holmes EW (1990) Characterization of the human and rat myoadenylate deaminase genes. J Biol Chem 265: 9423–9433
Sabina RL, Fishbein WN, Pezeshkpour G, Clarke PRH, Holmes EW (1992) Molecular analysis of the myoadenylate deaminase deficiencies. Neurology 42: 170–179
Shiraki H, Ogawa H, Matsuda Y, Nakagawa H (1979) Interaction of rat muscle AMP deaminase with myosin. I. Biochemical study of the interaction of AMP deaminase and myosin in rat muscle. Biochim Biophys Acta 566: 335–344
Stankiewicz A, Spychala J, Skladanowski A, Zydowo M (1979) Comparative studies on muscle AMP-deaminase-I. Purification, molecular weight, subunit structure and metal content of the enzyme from rat, rabbit, hen, frog and pikeperch. Comp Biochem Physiol 62B: 363–369
Stankiewicz A (1981) Human muscle AMP-deaminase. Subunit structure, amino acid composition and metal content of the homogeneous enzyme. Int J Biochem 13: 1177–1183
Thompson JL, Sabina RL, Ogasawara N, Riley DA (1992) AMP deaminase histochemical activity and immunofluorescent isozyme localization in rat skeletal muscle. J Histochem Cytochem 40: 931–946
Tovmasian EK, Hairapetian RL, Bykova EV, Severin SE, Haroutunian AV (1990) Phosphorylation of the skeletal muscle AMP-deaminase by protein kinase C. FEBS Lett 259: 321–323
Wheeler TJ, Lowenstein JM (1979) Adenylate deaminase from rat muscle: regulation by purine nucleotides and orthophosphate in the presence of 150 mM KC1. J Biol Chem 254: 8994–8999
Wilson DK, Rudolph FB, Quiocho FA (1991) Atomic structure of adenosine deaminase complexed with a transition state analog: understanding catalysis and immuno deficiency mutations. Science 252: 1278–1284
Yun S-L, Suelter CH (1978) Human erythrocyte 5’-AMP aminohydrolase: purification and characterization. J Biol Chem 253: 404–408
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Verlag, Berlin Heidelberg
About this paper
Cite this paper
Mahnke-Zizelman, D.K., Bausch-Jurken, M.T., Sabina, R.L. (1993). The AMP Deaminase Multigene Family in Rats and Humans. In: Gresser, U. (eds) Molecular Genetics, Biochemistry and Clinical Aspects of Inherited Disorders of Purine and Pyrimidine Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84962-6_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-84962-6_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-84964-0
Online ISBN: 978-3-642-84962-6
eBook Packages: Springer Book Archive