Zusammenfassung
Merkmal der organischen Psychosyndrome ist die enge Beziehung zwischen einer exogenen, organischen Störung der Funktion des Zentralnervensystems einerseits und einer daraus resultierenden psychischen Veränderung andererseits. Der Nachweis monokausaler Zusammenhänge steht allerdings noch aus. Es gibt Substanzen (z. B. Reserpin und Amphetamin), die über spezifische Mechanismen in die Synthese bzw. Speicherung spezifischer Neurotransmitter eingreifen. Auch sind kausale ätiologische Zusammenhänge mit der Wirkung von Rezeptoragonisten (LSD, endogenen Liganden des Benzodiazepinrezeptors, Endozepinen) und Rezeptorantagonisten (Anticholinergika, PCP) bekannt. Und schließlich treten organische Psychosyndrome im Rahmen unterschiedlicher Endokrinopathien auf. Eine monokausale Betrachtungsweise ist unter anderem deshalb so schwierig, weil viele exogene Faktoren zumindest teilweise konvergierend auf ein bestimmtes synaptisches System einwirken können
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Literatur
Basile AS, Hughes RD, Harrison PM, Murata Y, Panell L, Jones EA, Williams R, Skolnick P (1991) Elevated brain concentrations of 1,4-Benzodiazepines in fulminant hepatic failure. N Engl J Med 325:473–478
Basile AS (1991) The contribution of endogenous benzodiazepine receptor ligands to the pathogenesis of hepatic encephalopathy. Synapse 7:141–150
Bein HJ (1982) Rauwolfia and biological psychiatry. Trends Pharmacol Sci 3:37–39
Byrne A, Kirby B, Zibin T, Ensminger S ( 1991 ) Psychiatric and neurological effects of chronic solvent abuse. Can J Psychiatry 36:735–739
Bose M v, Zaudig M (1991) Neuro-psychiatrische Störungen durch organische Lösungsmittel. PsychiatrPrax 18:25–29
Cummings JL (1988) Review articles — organic psychosis. Psychosomatics 29:16–26
Ellison GD, Eison MS (1983) Continuous amphetamine intoxication: an animal model of the acute psychotic episode. Psychol Med 13:751–761
Freilich JS, Weiss B (1983) Altered adaptive capacity of brain catecholaminergic receptors during aging. In: Samuel D (ed) Aging of the brain, Raven-Press, New York, pp 277–300
Greenberg LH, Weiss B (1979) Ability of aged rats to alter beta adrenergic receptors of brain in response to repeated administration of reserpine and desmethylimipramine. J Pharmacol Exp Ther 211:309–316
Greenberg LH, Weiss B (1983) Neuroendocrine control of catecholaminergic receptors in aging brain. In: Agnoli A (ed) Aging, vol. 23: Aging brain and ergot alkaloids. Raven-Press, New York, pp 37–52
Grimm G, Ferenzi P, Katzenschlager R et al. (1988) Improvement of hepatic encephalopathy treated with flumazenil. Lancet i: 1292–1294
Groβ G, Brodde OE, Schümann HJ (1980) Decreased number of a-adrenoceptors in cerebral cortex of hypothyroid rats. Eur J Pharmacol 61:191–194
Hein HO, Suadicani P, Gyntelberg F (1990) Mixed solvent exposure and cerebral symptoms among active and retired workers. An epidemiological investigation of 3387 men aged 53-75 years. Acta Neurol Scand 81:97–102
Hermle L, Oepen G, Spitzer M (1988) Zur Bedeutung der Modellpsychosen. Fortschr Neurol Psychiatr 56:48–58
Hermle L, Spitzer M, Borchardt D, Gouzoulis E (1992) Beziehungen der Modell-bzw. Drogenpsychosen zu schizophrenen Erkrankungen. Fortschr Neurol Psychiatr 60:383–392
Hermle L, Fünfgeld M, Oepen G, Botsch H, Borchardt D, Gouzoulis E, Fehrenbach RA, Spitzer M (1993) Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects. Experimental psychosis as a tool for psychiatric research. Biol Psychiatr (in press)
Hurlbut KM (1991) Drug-induced psychoses. Emergency medicine. Clin North Am 9:31–52
Joels M, Bouma G, Hesen W, Zegers Y (1991) Increased effect of noradrenaline on synaptic responses in rat CA1 hippocampal area after adrenalectomy. Brain Res 550:347–352
Kelly WF, Checkley SA, Bender DA, Mashiter K (1983) Cushing’s syndrome and depression — A prospektive study of 26 patients. Br J Psychiatr 142:16–19
Kendall DA, Duman R, Slopis J, et al (1982) Influence of adrenocorticotropin hormone and yohimbine on antidepressant-induced declines in rat brain neurotransmitter receptor binding and function. J Pharmacol Exp Ther 222:566–571
Lauter H (1988) Die organischen Psychosyndrome. In: Kisker KP, Lauter H, Meyer JE, Müller C, Strömgren E (Hrsg) Psychiatrie der Gegenwart, Organische Psychosen, Bd. 6. Springer, Berlin Heidelberg New York London Paris Tokyo, S 3–56
Mendels J, Frazer A (1974) Brain biogenic amine depletion and mood. Arch Gen Psychiatry 30:447–451
Miller N, Gold M, Millman R (1988) PCP: A dangerous drug. AFP 38:215–218
Mobley Ph L, Sulser F ( 1980) Adrenal corticoids regulate sensitivity of noradrenaline receptor-coupled adenylate cyclase in brain. Nature 286:608–609
Müller WE (1985) Neurobiochemische Wirkung von Amitriptylin und anderen Antidepressiva. In: Beckmann H (Hrsg) Wie aktuell ist Amitriptylin für die Therapie der Depression. Das Ärztliche Gespräch, Bd 37, Tropon Köln, S 21–32
Müller WE ( 1992) Chemische Neurotransmission 1-4. Ärztliche Praxis 82:20–22,83:18-20,84:22-23, 85:11-12
Müller WE (1993) ZNS und peripheres Nervensystem. In: Greim H, Deml E (Hrsg) Toxikologie für Chemiker und Biologen. VCH Verlag, Weinheim, im Druck
Müller WE, Snyder SH (1977) y-Aminolevuline add: Influences on synaptic GAB A receptor binding may explain CNS symptoms of porphyria. Ann Neurol 2:340–342
Müller WE, Riederer P, Kienzl E (1992) Grundlegende Aspekte zur Neurotransmission. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka, Bd. I. Springer, Wien, S 221–248
Pearlson GD (1981) Psychiatric and medical syndromes associated with phencyclidine (PCP) abuse. The John Hopkins Medical Journal 148:25–33
Perry SW, Markowitz J (1988) Organic mental disorders. In: Talbott JA, Hales RE, Yodofsky SC (eds) Textbook of psychiatry. The American Psychiatric Press, Washington, pp 279–311
Petitti N, Etgen AM (1990) α1-adrenoceptor augmentation of β-stimulated cAMP formation is enhanced by estrogen and reduced by progesterone in rat hypothalamic slices. J Neurosci 10:2842–2849
Pierce PA, Peroutka SJ (1989) Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex. Psychopharmacology 97:118–122
Pottash A, Black HR, Gold MS (1981) Psychiatric complications of antihypertensive medications. J Nerv Ment Dis 169:430–438
Ridley RM, Baker HF, Owen F, Cross AJ, Crow TJ (1983) Behavioural and biochemical effects of chronic treatment with amphetamine in the vervet monkey. Neuropharmacology 22:551–554
Rothstein JD, Guidotti A, Tinuper P, Cortelli P, Avoni P, Plazzi G, Lugaresi E, Schoch P, Montagna P (1992 a) Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor. Lancet 340:1002–1004
Rothstein JD, Garland W, Puia G, Guidotti A, Weber R, Costa E (1992 b) Purification and characterization of naturally occuring benzodiazepine receptor ligands. J Neurochem 58:2102–2115
Schultz JE, Rösch H (1991) Differential effects of ovarian steroid hormones on α-adrenoceptor downregulation caused by the antidepressants imipramine and rolipram. Naunyn-Schmiedeberg’s Arch Pharmacol 344:437–441
Scollo-Lavizzari G, Steinmann E (1985) Reversal of hepatic coma by benzodiazepine antagonist (Ro 15-1788). Lancet 1:1324
Sulser F (1983) Deamplification of noradrenergic signal transfer by antidepressants: A unified catecholamine-serotonin hypothesis of affective disorders. Psychopharm Bull 19:300–304
Tune LE, Bylsma FW (1991) Benzodiazepine-induced and anticholinergic-induced delirium in the elderly. Int Psychogeriatr 3:397–408
Wachtel H, Turski L (1990) Glutamate: a new target in schizophrenia? Trends Pharmacol Sci 11:219–220
Wagner HR, Davies JN (1980) Decreased β-adrenergic responses in the female rat brain are eliminated by ovariectomy: correlation of 3H-dihydroalprenolol binding and catecholamine stimulated cyclic AMP levels. Brain Res 201:235–239
White FJ (1986) Comparative effects of LSD and lisuride: clues to specific hallucinogenic drag actions. Pharmacol Biochem Behav 24:365–379
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Müller, W.E., Hartmann, H. (1993). Exogene Störungen der zentralen Neurotransmission. In: Schüttler, R. (eds) Organische Psychosyndrome. Tropon-Symposium, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84961-9_3
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