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Immunocytochemistry in Diagnostic Cytology

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Current Status of Diagnostic Cytology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 133))

Abstract

Immunocytochemistry is now a well-established tool for tumor typing in surgical pathology. However, in diagnostic cytology it has not yet been generally accepted. Koss (1990) says that “. . . the staining of cytologie preparations with a battery of antibodies to the various cell components or products is very costly and rarely rewarding,. . . the results of immunocytochemistry vary according to the batch of antibodies and the technical skills of the laboratories, the interpretation of the results is not always easy, and the problem with borderline positive stains is often perplexing.” Other authors (Chess and Hajdu 1986; van Flens et al. 1990; Mason and Bedrossian 1986), too, are not as enthusiastic as some of the pioneering cytolgists (Nadij 1980). Chess and Hajdu (1986) found only 63% positive reactions and 88% negative reactions to be in agreement with the cytologie diagnosis, Van Flens et al. (1990) estimated that immunocytochemistry contributed to diagnosis in about 50% of cases.

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Authors and Affiliations

  1. Institute for Pathology, Division of Cytology, University of Basel, CH-4003, Basel, Switzerland

    P. Dalquen, G. Sauter, R. Epper, B. Kleiber, G. Feichter & F. Gudat

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  1. P. Dalquen
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  2. G. Sauter
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  3. R. Epper
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  4. B. Kleiber
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  5. G. Feichter
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  6. F. Gudat
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Editors and Affiliations

  1. Institute for Cytopathology Center for Pathology, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany

    Peter Pfitzer

  2. Gerhard Domagk Institute for Pathology, University of Münster, Domagkstr. 17, 48149, Münster, Germany

    E. Grundmann

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Dalquen, P., Sauter, G., Epper, R., Kleiber, B., Feichter, G., Gudat, F. (1993). Immunocytochemistry in Diagnostic Cytology. In: Pfitzer, P., Grundmann, E. (eds) Current Status of Diagnostic Cytology. Recent Results in Cancer Research, vol 133. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84951-0_6

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