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The Molecular Basis of Genetic Defects in HDL Metabolism

  • Conference paper
Cellular Metabolism of the Arterial Wall and Central Nervous System

Part of the book series: Sitzungsberichte der Heidelberger Akademie der Wissenschaften ((3027,volume 1993/94 / 1993/1))

  • 45 Accesses

Abstract

Plasma high density lipoproteins (HDL) have been the focus of active research over the last two decades since HDL-cholesterol have been inversely associated with the risk of premature cardiovascular disease, respectively (1–4). HDL have been proposed to modulate the development of premature vascular disease by facilitating the removal of excess cholesterol from peripheral tissues and transporting the cholesterol directly back to the liver or transferring the cholesterol to VLDL or LDL by the cholesterol ester exchange protein (CETP) (5–7). The process of HDL mediated transport of cholesterol from peripheral tissues back to the liver has been termed reverse cholesterol transport (8,9) and remains to be definitively confirmed.

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Author information

Authors and Affiliations

  1. National Institutes of Health, National Heart, Lung, and Blood Institute, Molecular Disease Branch, Building 10, Room 7N117 9000, Rockville Pike, Bethesda, Bethesda, Maryland, 20982, USA

    Prof. Dr. H. Bryan Brewer, Daniel J. Rader, Hanns-Georg Klein, Katsunori Ikewaki & Silvia Santamarina-Fojo

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  1. Prof. Dr. H. Bryan Brewer
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  2. Daniel J. Rader
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  3. Hanns-Georg Klein
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  4. Katsunori Ikewaki
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  5. Silvia Santamarina-Fojo
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Editor information

Editors and Affiliations

  1. Heidelberger Akademie der Wissenschaften, Karlstraße 4, W-6900, Heidelberg, Germany

    Gotthard Schettler (Leiter der Geomedizinischen Forschungsstelle) (Leiter der Geomedizinischen Forschungsstelle)

  2. Universitäts-Krankenhaus Eppendorf, Martinistraße 52, W-2000, Hamburg 20, Germany

    Heiner Greten (Direktor der Medizinischen Kernklinik und Poliklinik) (Direktor der Medizinischen Kernklinik und Poliklinik)

  3. Abt. Innere Medizin I, Medizinische Universitätsklinik, Bergheimerstraße 58, W-6900, Heidelberg, Germany

    Andreas J. R. Habenicht

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© 1993 Springer-Verlag Berlin Heidelberg

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Brewer, H.B., Rader, D.J., Klein, HG., Ikewaki, K., Santamarina-Fojo, S. (1993). The Molecular Basis of Genetic Defects in HDL Metabolism. In: Schettler, G., Greten, H., Habenicht, A.J.R. (eds) Cellular Metabolism of the Arterial Wall and Central Nervous System. Sitzungsberichte der Heidelberger Akademie der Wissenschaften, vol 1993/94 / 1993/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84949-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-84949-7_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56603-8

  • Online ISBN: 978-3-642-84949-7

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