Cellular Interactions in Atherogenesis
The very early atherosclerotic lesion (fatty streak) as well as advanced lesions consist of functionally altered endothelial cells, differentiated macrophages, activated T-lymphocytes, and proliferating smooth muscle cells (Ross 1986; Schwartz et al. 1991). These cells are able to secrete multiple biologically active molecules. By means of these mediators the cells can interact with each other, affecting the state of differentiation and proliferation of other neighbouring vascular cells.
KeywordsFoam Cell Fatty Streak Macrophage Differentiation Human Aortic Smooth Muscle Cell Early Atherosclerotic Lesion
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