The Relationship Between Chemically-Induced Meiotic Delay and Aneuploidy in Mouse Oocytes and Zygotes
Aneuploidy is a relatively common genetic disorder that results in human morbidity and mortality. Approximately 30% of embryonic and fetal deaths and 3.45 per thousand livebirths are associated with an abnormal number of chromosomes (Hook, 1985). Unfortunately, very little is known about the etiology and mechanisms of chromosome missegregation. This situation dictates that considerable research be directed toward understanding the causes of aneuploidy. Although several hypotheses have been advanced for the etiology of aneuploidy (Bond and Chandley, 1983), there still exists a paucity of information about the direct causes and mechanisms of aneuploidy production. Without such specific knowledge, there is little hope of reducing the incidence of aneuploidy in humans. Some progress has been made. We now know that various chemicals can induce aneuploidy by interacting with certain cellular organelles, especially components of the spindle apparatus. These results have been demonstrated in various organisms and cell types both in vivo and in vitro (Dellarco et al., 1986).
KeywordsColchicine Alan Vinblastine Benomyl Griseofulvin
Unable to display preview. Download preview PDF.
- Bajer A, Mole-Bajer J (1963) Cine analysis of some aspects of mitosis in endosperm. In: Rose G (ed) Cinematography in cell biology. Academic Press New York, pp. 357–409Google Scholar
- Bond DJ, Chandley AC (1983) Aneuploidy, Oxford monographs on medical genetics No. 11. Oxford Univ. Press New YorkGoogle Scholar
- Calabresi P, Parks Jr.RE (1975) Alkylating agents, antimetabolites, hormones, and other antiproliferative agents. In: Goodman LS, Gilman A (eds) The Pharmacological Basis of Therapeutics, 5th Ed. Macmillan New York, pp 1254–1307Google Scholar
- Dellarco VL, Mavournin KH, Waters MD, Rogers ET (1986) Aneuploidy: methodology and test data review. Mutat Res 167:1–188Google Scholar
- Hook EB (1985) The impact of aneuploidy upon public health: mortality and morbidity associated with human chromosome abnormalities. In: Dellarco VL, Voytek PE, Hollaender A (eds) Aneuploidy — etiology and mecahnisms. Plenum New York, pp. 7–33Google Scholar
- Mailhes JB (1987) Incidence of aneuploidy in rodents. In: Vig BK, Sandberg AA (eds) Aneuploidy, part A: incidence and etiology. Alan R Liss, Inc. New York, pp. 67–101Google Scholar
- Mailhes JB, Marchetti F, Aardema MJ (1992) Griseofulvin-induced aneuploidy and meiotic delay in mouse oocytes: effects of dose and harvest time, (submitted to Mutation Research)Google Scholar
- Marchetti F, Mailhes JB (1992) Unpublished results.Google Scholar
- Pacchierotti F (1988) Chemically induced aneuploidy in germ cells of mouse. In: Vig BK, Sandberg AA (eds) Aneuploidy, part B: Induction and test systems. Alan R. Liss Inc. New York, pp. 123–139Google Scholar