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RCC1-Ran-RanGAP Signal for Initiation of Mitosis

  • Herwig Ponstingl
  • F. Ralf Bischoff
Conference paper
Part of the NATO ASI Series book series (volume 72)

Abstract

In most eukaryotic cells checkpoints ensure that DNA replication is completed before the onset of mitosis. Experimentally these controls can be overrun, e.g., by fusion of S-phase cells with mitotic cells (Johnson and Rao, 1970), by adding 5 mM caffeine (Schlegel and Pardee, 1986) to the medium of S-phase cells, or by okadaic acid (Yamashita et al., 1990), resulting in premature condensation of the chromosomes and in their ‘pulverized’ appearance under the microscope.

Keywords

Okadaic Acid Chromosome Condensation Premature Chromosome Condensation Mitotic Control p34Cdc2 Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Herwig Ponstingl
    • 1
  • F. Ralf Bischoff
    • 1
  1. 1.Project Molecular Biology of MitosisDeutsches KrebsforschungszentrumHeidelbergGermany

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