Vitamin E-Responsive Hemolytic Anemia and Necrotizing Myopathy, Owl Monkeys

  • Norval W. KingJr.
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The gross findings in owl monkeys with vitamin E-responsive hemolytic anemia and necrotizing myopathy vary. Pallor of mucus membranes, skeletal musculature and visceral organs resulting from the anemia is the most common finding in animals dying of this disorder. There may also be variable degrees of atrophy of skeletal muscle. The tissues of some affected animals may also be icteric. The spleen and liver may be enlarged and browner than normal. The livers of animals with extremely severe anemia, i.e., hemoglobin values less than 5.0 g/dl (normal 14.2 ± 1.7), frequently have a characteristic red-tan reticular (“nutmeg”) pattern. The bone marrow of long bones is typically dark red rather than yellow and fatty. Finally, randomly scattered petechiae may be present in the cerebrum, cerebellum and brainstem.


α-Tocopherol-responsive hemolytic anemia white muscle disease nutritional myopathy owl monkey anemia 


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© Springer-Verlag Berlin Heidelberg 1993

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  • Norval W. KingJr.

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