Pyrophosphate Arthropathy, Macaca mulatta

  • E. Donald Roberts
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Pseudogout is a disease of the joints and intervertebral disc and is associated with chronic degenerative joint disease of primarily the knee articular cartilage and menisci. Cartilage changes are characterized by marginal erosion of cartilage, ulceration, fibrillation of articular cartilage and osteophyte formation (Fig. 149). The chronic knee joint changes are also associated with muscle and tendon contraction, which prevents the extension of the knee joint. If sufficient quantity of the pyrophosphate crystals are present, a focal whitish discoloration of the cartilage or menisci will be evident (Fig. 149). Radiographically, focal radio-densities may be observed in the affected tissues (Kessler et al. 1986).

Synonyms

Pseudogout calcium pyrophosphate deposition disease chondrocalcinosis 

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References

  1. Bennett RM, Lehr JR, McCarty DJ (1976) Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure. Arthritis Rheum 19:93–97PubMedCrossRefGoogle Scholar
  2. Cotchin (1960) Calcium gout (kalkgicht) and calcinosis circumscripta in dogs. Br J Vet 116:3–8Google Scholar
  3. Gibson JP, Roenigk WJ (1972) Pseudogout in a dog. JAVMA 161:912–915Google Scholar
  4. Hunter GK (1987) An ion-exchange mechanism of cartilage calcification. Connect Tissue Res 16:111–120PubMedCrossRefGoogle Scholar
  5. Ishikawa K, Masuda I, Ohira T, Shi K, Yokoyama M, Shi K (1989) A histologic study of calcium pyrophosphate dihydrate crystal-deposition disease. J Bones Joint Surg [Am] 71A:875–886Google Scholar
  6. Kandel RA, Renlund RC, Cheng PT, Rapley WA, Mehren KG, Pritzker K PH (1983) Calcium pyrophosphate dihydrate crystal deposition disease with concurrent vertebral hyperostosis in a Barbary ape. Arthritis Rheum 26:682–687PubMedCrossRefGoogle Scholar
  7. Kessler MJ, Turnquist JE, Pritzker KPH, London WT (1986) Reduction of passive extension and radiographic evidence of degenerative knee joint diseases in cagedraised and freeranging aged rhesus monkeys (Macaca mulatta). J Med Primatol 15:109Google Scholar
  8. Kohn NN, Hughes RE, McCarty DJ Jr, Farres JS (1962) The significance of calcium phosphate crystals in the synovial fluid of arthritic patients: the pseudogout syndrome II. Identification of crystals. Ann Intern Med 56:738–745PubMedGoogle Scholar
  9. Mandel NS, Mandel GS, Carroll DJ, Halverson PB (1984) Calcium pyrophosphagte crystal deposition. An invitro study using a gelatin matrix model. Arthritis Rheum. 27:789–796PubMedCrossRefGoogle Scholar
  10. McCarty DJ Jr (1962) Phagocytosis of urate crystals in gouty synovial fluid. Am J Med Sci 243:288–95CrossRefGoogle Scholar
  11. McCarty DJ Jr (1963) Crystal-induced inflammation syndromes of gout and pseudo-gout. Geriatrics 18:467–78PubMedGoogle Scholar
  12. McCarty DJ, Kozin F (1975) An overview of cellular and molecular mechanisms in crystal induced inflammation. Arthritis Rheum 18:757–764PubMedCrossRefGoogle Scholar
  13. Owen LN (1967) Calcinosis circumscripto (calcium gout) in related Irish wolfhounds. J Small Anim Pract 8:291–292PubMedCrossRefGoogle Scholar
  14. Pritzker KPH, Cheng PT, Adams ME, Nyburg SC (1978) Calcium pyrophosphate dehydrate crystal formation in model hydrogels. J Rheumatol 5:469–473PubMedGoogle Scholar
  15. Pritzker KPH, Renlund RC, Chen P-T (1983) Which comes first — crystals or osteoarthritis? A study of surgically removed femoral heads. J Rheumatol 10 [Suppl 9]:38–39Google Scholar
  16. Renlund RC, Pritzker KPH, Cheng P-T, Kessler MJ (1986) Rhesus monkeys (Macaca mulatta) as a model for calcium pyrophosphate dihydrate crystal deposition disease. J Med Primatol 15:11–16PubMedGoogle Scholar
  17. Resnik CS, Resnik D (1983) Crystal deposition disease. Semin Arthritis Rheum 12:390–403PubMedCrossRefGoogle Scholar
  18. Roberts ED, Baskin GB, Watson E, Henk WG, Shelton TC, Bowen MS (1984a) Calcium pyrophosphate deposition in nonhuman primates. Vet Pathol 21:592–596PubMedGoogle Scholar
  19. Roberts ED, Baskin GB, Watson E, Henk WG, Shelton TC (1984b) Animal model of human disease: calcium pyrophosphate deposition disease (CPDD) in nonhuman primates. Am J Pathol 116:359–361PubMedGoogle Scholar
  20. Roughley PJ, White RJ (1980) Age-related changes in the structure of protoglycan subunits from human articular cartilage. J Biol Chem 255:217–224PubMedGoogle Scholar
  21. Tenenbaum J, Pritzker KPH, Gross AE, Cheng P-T, Renlund RC (1981) The effects of intraarticular corticosteroids in articular cartilage. Semin Arthritis Rheum 11:140–141CrossRefGoogle Scholar
  22. Woodard JC, Shields RP, Aldrich HC, Carter RL (1982) Calcium pyrophosphate deposition disease in Great Danes. Vet Pathol 19:464–485PubMedCrossRefGoogle Scholar
  23. Yosipovitch ZH, Glimcher MJ (1972) Articular chondrocalcinosis: hydroxyapatite deposition disease in adult mature rabbits. J Bone Joint Surg [Am] 54A:841–853Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

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  • E. Donald Roberts

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