Pyrophosphate Arthropathy, Macaca mulatta

  • E. Donald Roberts
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Pseudogout is a disease of the joints and intervertebral disc and is associated with chronic degenerative joint disease of primarily the knee articular cartilage and menisci. Cartilage changes are characterized by marginal erosion of cartilage, ulceration, fibrillation of articular cartilage and osteophyte formation (Fig. 149). The chronic knee joint changes are also associated with muscle and tendon contraction, which prevents the extension of the knee joint. If sufficient quantity of the pyrophosphate crystals are present, a focal whitish discoloration of the cartilage or menisci will be evident (Fig. 149). Radiographically, focal radio-densities may be observed in the affected tissues (Kessler et al. 1986).


Pseudogout calcium pyrophosphate deposition disease chondrocalcinosis 


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© Springer-Verlag Berlin Heidelberg 1993

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  • E. Donald Roberts

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