Eukaryotic Mdr1/P-Glycoprotein Homologues: Unconventional Secretion Processes Mediated by a Growing Family of ATP-Dependent Membrane Translocators
Mdr1/P-glycoprotein, when overexpressed, can confer resistance of human tumor cells to multiple lipophilic cytotoxic drugs and this resistance is a major problem in cancer chemotherapy. When mouse and human mdr cDNAs were cloned and sequenced (10,17), one of the intriguing findings was that they showed homology to a family of bacterial active transport systems, including for example the E. coli hlyB gene, whose product is a membrane protein involved in the export of a hemolysin. This observation was the start of what has since been a very active and fruitful area of research, and in the past few years many Mdr/P-glycoprotein homologues have been identified in eukaryotes.
KeywordsCystic Fibrosis Transmembrane Conductance Regulator Multiple Drug Resistance Chloroquine Resistance Major Histocompatibility Class Mating Pheromone
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