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Eukaryotic Mdr1/P-Glycoprotein Homologues: Unconventional Secretion Processes Mediated by a Growing Family of ATP-Dependent Membrane Translocators

  • Mikael Göransson
  • Jeremy Thorner
Conference paper
Part of the NATO ASI Series book series (volume 71)

Abstract

Mdr1/P-glycoprotein, when overexpressed, can confer resistance of human tumor cells to multiple lipophilic cytotoxic drugs and this resistance is a major problem in cancer chemotherapy. When mouse and human mdr cDNAs were cloned and sequenced (10,17), one of the intriguing findings was that they showed homology to a family of bacterial active transport systems, including for example the E. coli hlyB gene, whose product is a membrane protein involved in the export of a hemolysin. This observation was the start of what has since been a very active and fruitful area of research, and in the past few years many Mdr/P-glycoprotein homologues have been identified in eukaryotes.

Keywords

Cystic Fibrosis Transmembrane Conductance Regulator Multiple Drug Resistance Chloroquine Resistance Major Histocompatibility Class Mating Pheromone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Mikael Göransson
    • 1
  • Jeremy Thorner
    • 1
  1. 1.Division of Biochemistry and Molecular Biology Department of Molecular and Cell BiologyUniversity of CaliforniaBerkeleyUSA

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