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Fibromatosis in Macaques Infected with Type D Retroviruses

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Nonhuman Primates I

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

The two anatomic locations of these lesions led to the designations retroperitoneal and subcutaneous fibromatosis. The course of the disease also occurs in two forms: localized and progressive. In the localized form, a nodular or multinodular proliferation of fibromatous tissue is found beneath the peritoneum at the mesenteric attachment of the ileocecal junction and/or adjacent lymph nodes (Fig. 46). These lesions vary from 1 to 4 cm in diameter, are very firm and pale, and resist cutting. Most localized lesions remain at one site but some become progressive, particularly in monkeys that manifest simian acquired immunodeficiency syndrome (SAIDS) (Giddens et al. 1985; Tsai et al. 1985a,b, 1986). In a few affected monkeys the localized lesions undergo spontaneous regression.

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References

  • Barre’-Sinoussi F, Chermann J-C, Rey F, Nugeyre MT, Chamaret S, Greust J, Dauguet C, Axler-Blin C, Vezimet-Brum F, Rouzioux C, Rozenbaum W, Montagnier L (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome ( AIDS ). Science 220: 868–871

    Article  Google Scholar 

  • Benveniste RE, Stromberg K, Morton WR, Tsai C-C, Giddens WE Jr (1986) Association of retroperitoneal fibromatosis with type D retroviruses. In: Salzman LA (ed) Animal models of retrovirus infection and their relation to AIDS. Academic, San Diego, pp 335–353

    Google Scholar 

  • Beral V, Peterman TA, Berkelman RL, Jaffe HW (1990) Kaposi’s sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 335I: L123 –128

    Article  Google Scholar 

  • Bryant ML, Marx PA, Shiigi SM, Wilson BJ, McNulty WP, Gardner MB (1986) Distribution of type D retroviral sequences in tissues of macaques with simian acquired immune deficiency and retroperitoneal fibromatosis. Virology 150: 149–160

    Article  PubMed  CAS  Google Scholar 

  • Dorfman RF, Wood GS, Beckstead JH (1988) Histogenesis. In: Ziegler JL, Dorfman RF (eds) Kaposi’s sarcoma. Dekker, New York, pp 71–112

    Google Scholar 

  • Ensoli B, Nakamura S, Salahuddin SZ, Biberfield P, Larsson L, Beaver B, Wong-Staal F, Gallo RC (1989) AIDS-Kaposi’s sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. Science 243: 223–226

    Article  PubMed  CAS  Google Scholar 

  • Fauci AS, Masur H, Gelmann EP, Markham PD, Hahn BH, Lane HC (1985) The acquired immunodeficiency syndrome: an update. Ann Intern Med 102: 800–813

    PubMed  CAS  Google Scholar 

  • Friedman-Kien AE, Laubenstein LJ, Rubinstein P, Buimovici-Klein E, Marmor M, Stahl R, Spigland I, Kim KS, Zolla-Pazner S (1982) Disseminated Kaposi’s sarcoma in homosexual men. Ann Intern Med 96:693– 700

    PubMed  CAS  Google Scholar 

  • Gallo RC, Salahuddin SZ, Popovic M, Shearer GM, Kaplan M, Haynes BF, Palker TJ, Redfield R, Oleske J, Safai B, White G, Foster P, Markham PD (1984) Frequent detection and isolation of cytopathic retroviruses ( HTLV-III) from patients with AIDS and at risk for AIDS. Science 224: 500–503

    Article  PubMed  CAS  Google Scholar 

  • Gardner MB, Marx PA (1985) Simian acquired immunodeficiency syndrome. In: Klein G (ed) Viruses as the causative agents of naturally occurring tumors. Advances in viral oncology, vol 5. Raven, New York, pp 57–81

    Google Scholar 

  • Giddens WE Jr, Bielitzki JT, Morton WR, Ochs HD, Meyers MS, Blakely GA, Boyce JT (1979) Idiopathic retroperitoneal fibromatosis: an enzootic disease in the pigtailed monkey Macaca nemestrina. Lab Invest 40: 294 (abstr)

    Google Scholar 

  • Giddens WE Jr, Morton WR, Hefti E, Panem S, Ochs H (1983) Enzootic retroperitoneal fibromatosis in Macaca spp. In: Kalter SS (ed) Viral and immunological diseases in nonhuman primates. Liss, New York, pp 249–253

    Google Scholar 

  • Giddens WE Jr, Tsai C-C, Morton WR, Ochs HD, Knitter GH, Blakely GA (1985) Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques. Pathologic observations and transmission studies. Am J Pathol 119: 253–263

    PubMed  Google Scholar 

  • Gottlieb MS, Groopman JE, Weinstein WM, Fahey JL, Detels R (1983) The acquired immunodeficiency syndrome. Ann Intern Med 99: 208–220

    PubMed  CAS  Google Scholar 

  • London WI, Madden DL, Gravell M, Dalakas MC, Houff SA, Sever JL, Henrickson RV, Maul DH, Osborn KG, Gardner MB (1983) Experimental transmission of simian acquired immunodeficiency syndrome (SAIDS) and Kaposi-like skin lesions. Lancet 2:869– 873

    Article  PubMed  CAS  Google Scholar 

  • Lowenstine LJ, Lerche NW (1988) Retrovirus infections of nonhuman primates: a review. J Zoo Anim Med 19: 168–187

    Article  Google Scholar 

  • Lowenstine L, Lerche N, Jennings M, Marx P, Gardner M, Pedersen N (1988) An epizootic of simian AIDS caused by SIV in captive macaques in the 1970’s. In: Girard M, Valette L (eds) Retroviruses of human A.I.D.S. and related animal diseases. 2nd Colloquium of the Cent Gardes, Foundation Marcel Merieux, Lyon, pp 174–176

    Google Scholar 

  • Marx PA, Lowenstine LJ (1987) Menechyman neoplasms associated with type D retroviruses in macaques. Cancer Surv 6: 101–115

    PubMed  CAS  Google Scholar 

  • Marx PA, Bryant ML, Osborn KG, Maul DH, Lerche NW, Lowenstine LJ, Kluge JD, Zaiss CP, Henrickson RV, Shiigi SM, Wilson BJ, Malley A, Olson LC, McNulty WP, Arthur LO, Gilden RV, Barker CS, Hunter E, Munn R, Herdecker G, Gardner MB (1985) Isolation of a new serotype of simian acquired immune deficient syndrome type D retrovirus from Celebes black macaques ( Macaca nigra) with immune deficiency and retroperitoneal fibromatosis. J Virol 56: 571–578

    PubMed  CAS  Google Scholar 

  • Meduri GU, Stover DE, Lee M, Myskowski PL, Caravelli JF, Zaman MB (1986) Pulmonary Kaposi’s sarcoma in the acquired immune deficiency syndrome. Clinical, radiographic and pathologic manifestations. Am J Med 81: 11–18

    Article  PubMed  CAS  Google Scholar 

  • Nakamura S, Salahuddin SZ, Biberfield P, Ensoli B, Markham PD, Wong-Staal F, Gallo RC (1988) Kaposi’s sarcoma cells: long-term culture with growth factor from retrovirus-infected CD4+ T cells. Science 242: 426–430

    Article  PubMed  CAS  Google Scholar 

  • Osborn KG, Prahalada S, Lowenstine LJ, Gardner MB, Maul DH, Henrickson RV (1984) The pathology of a enzootic acquired immunodeficiency in rhesus macaques. Am J Pathol 114: 94–103

    PubMed  CAS  Google Scholar 

  • Power MD, Marx PA, Bryant ML, Gardner MB, Barr PJ, Luciw PA (1986) The necleotide sequence of a type D retrovirus (SRV-1) etiologically linked with the simian acquired imunodeficiency syndrome. Science 231: 1567–1572

    Article  PubMed  CAS  Google Scholar 

  • Purdy LJ, Colby TV, Yousem SA, Battifora H (1986) Pulmonary Kaposi’s sarcoma: premortem histologic diagnosis. Am J Surg Pathol 10: 301–311

    Article  PubMed  CAS  Google Scholar 

  • Roodman ST, Woon MD, Hoffman JW, Theodorakis P, Tsai CC, Wu H-N, Tsai C-C (1991) Interleukin-6 and retroperitoneal fibromatosis from SRV-2-infected macaques with simian AIDS. J Med Primatol 20:201– 205

    PubMed  CAS  Google Scholar 

  • Safai B, Johnson KG, Myskorvski PL, Koziner B, Yang SY, Cunningham-Rundles S, Godbold JH, Dupont BO (1985) The natural history of Kaposi’s sarcoma in the acquired immunodeficiency syndrome. Ann Intern Med 103: 744–750

    PubMed  CAS  Google Scholar 

  • Salahuddin SZ, Nakamura S, Biberfeld P, Kaplan MH, Markham PD, Larsson L, Gallo RC (1988) Angiogenic properties of Kaposi’s sarcoma-derived cells after long- term culture in vitro. Science 242: 430–433

    Article  PubMed  CAS  Google Scholar 

  • Saltz RK, Kurtz RC, Lightdale CJ, Myskowski KP, Cunningham-Rundles S, Urmacher C, Safai B (1984) Kaposi’s sarcoma. Gastrointestinal involvement, correlation with skin findings and immunologic function. Dig Dis Sci 29: 817–823

    Article  PubMed  CAS  Google Scholar 

  • Thayer RM, Power MD, Bryant ML, Gardner MB, Barr PJ, Luciw PA (1987) Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency syndrome. Virology 157: 317–327

    Article  PubMed  CAS  Google Scholar 

  • Tsai C-C, Blakely GA, Uno H, Frohna B, Warner TFCS (1984) Retroperitoneal fibromatosis (Kaposi’s sarcomalike tumor) with lymph node lesions in pigtaled macaques ( Macaca nemestrina ). Lab Invest 50: 61A

    Google Scholar 

  • Tsai C-C, Warner TFCS, Uno H, Giddens WE Jr, Ochs HD (1985a) Subcutaneous fibromatosis associated with an acquired immunodeficiency syndrome in pigtailed (Macaca nemestrina) macaques. Am J Pathol 120:30– 37

    CAS  Google Scholar 

  • Tsai C-C, Giddens WE Jr, Morton WR, Rosenkranz SL, Ochs HD, Benveniste RE (1985b) Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques: epidemiologic studies. Lab Anim Sci 35: 460–464

    PubMed  CAS  Google Scholar 

  • Tsai C-C, Giddens WE Jr, Ochs HD, Morton WR, Knitter GH, Blakely GA, Benveniste RE (1986) Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques: clinical and immunologic studies. Lab Anim Sci 35: 119–125

    Google Scholar 

  • Tsai C-C, Thouless ME, Morton WR, Benveniste RE (1988) Changing tumorigenesis of simian acquired immunodeficiency syndrome-associated type D retrovirus. Lab Invest 58: 95A

    Google Scholar 

  • Tsai CC, Tsai C-C, Sligh J, Roodman S (1989) Kaposi’s sarcoma-like cell line from simian AIDS with retroperitoneal fibromatosis (RF) associated with type D retrovirus (SRV-2) infection. Lab Invest 60: 98A

    Google Scholar 

  • Tsai CC, Tsai C-C, Roodman ST, Woon M-D (1990a) Mesenchymal tumor-like lesions (MTL) in simian AIDS associated with SRV-2 infection. J Med Primatol 19: 189–202

    PubMed  CAS  Google Scholar 

  • Tsai C-C, Wu H-N, Tsai CC (1990b) Phenotypic characterization of Kaposi’s sarcoma-like tumor associated with SAIDS-D retrovirus in pigtailed macaques. 8th annual symposium on nonhuman primate models for AIDS, New Orleans, November 1990, p 121

    Google Scholar 

  • Warner TFCS, Uno H, Tsai C-C, Giddens WE Jr (1984) Cutaneous Kaposi’s sarcoma-like tumor in pigtail macaques (Macaca nemestrina). Lab Invest 50:65–66A (abstr) Mycobacterium aviumintracellulare Infection 57

    Google Scholar 

  • Ziegler JL, Levy JA (1985) Acquired immunodeficiency syndrome and cancer. In: Klein G (ed) Viruses as the causative agents of naturally occurring tumors. Advances in viral oncology, vol 5. Raven, New York, pp 239–255

    Google Scholar 

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Authors
  1. Che-Chung Tsai
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Editor information

Editors and Affiliations

  1. ILSI Research Foundation, Harvard Medical School, 1126 Sixteenth Street, N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology Emeritus) (Professor of Comparative Pathology Emeritus)

  2. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

  3. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772, USA

    Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

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© 1993 Springer-Verlag Berlin Heidelberg

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Tsai, CC. (1993). Fibromatosis in Macaques Infected with Type D Retroviruses. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Nonhuman Primates I. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84906-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-84906-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84908-4

  • Online ISBN: 978-3-642-84906-0

  • eBook Packages: Springer Book Archive

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