Vitamin C Deficiency, Old and New World Monkeys
The response to vitamin C deficiency differs between the various primate species. The naturally occurring disease in squirrel monkeys (Saimiri sciureus) appears to involve mainly the head region, whereas in rhesus macaques (Macaca mulatta) the disease involves the long bones, teeth, and ribs. Petechiae to ecchymoses of gingiva, nasal cavity, subcutaneous tissue, and periosteum are basic lesions as vitamin C is essential to the production of collagen fibrils which are common to both vascular integrity and osteoid formation. In the squirrel monkey, the deficiency is manifest by pericranial hemorrhage forming large hematomas. The hematomas give the animal’s head the appearance of a “turban” and stretch and distort the facial features (Fig. 219).
KeywordsRhesus Macaque Squirrel Monkey World Monkey Spider Monkey Vervet Monkey
Unable to display preview. Download preview PDF.
- Manning PJ, Wagner JE, Harkness JE (1984) Biology and diseases of guinea pigs. In: Fox JG, Cohen BJ, Lowe FM (eds) Laboratory animal medicine. Academic, Orlando, pp 149–181Google Scholar
- Ratterree MS, Didier PJ, Blanchard JL, Clarke MR, Schaeffer D (1989) Vitamin C deficiency in captive nonhuman primates fed commercial primate diet. Lab Anim Sci 39: 101–106Google Scholar
- Richmond V, Stokstad ELR (1969) Effect of ascorbic acid on guinea pig skin collagen synthesis: I. Total collagen. J Dent Res 48/5:863–871Google Scholar
- Robbins SL, Cotran RS, Kumar V (eds) (1989) Pathologic basis of disease, 4th edn. Saunders, Philadelphia, pp 356–359Google Scholar