Vitamin C Deficiency, Old and New World Monkeys

  • E. Donald Roberts
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The response to vitamin C deficiency differs between the various primate species. The naturally occurring disease in squirrel monkeys (Saimiri sciureus) appears to involve mainly the head region, whereas in rhesus macaques (Macaca mulatta) the disease involves the long bones, teeth, and ribs. Petechiae to ecchymoses of gingiva, nasal cavity, subcutaneous tissue, and periosteum are basic lesions as vitamin C is essential to the production of collagen fibrils which are common to both vascular integrity and osteoid formation. In the squirrel monkey, the deficiency is manifest by pericranial hemorrhage forming large hematomas. The hematomas give the animal’s head the appearance of a “turban” and stretch and distort the facial features (Fig. 219).


Rhesus Macaque Squirrel Monkey World Monkey Spider Monkey Vervet Monkey 
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  1. Alvares O, Siegel I (1981) Permeability of gingival sulcular epithelium in the development of scorbutic gingivitis. J Oral Pathol 10: 40–48PubMedCrossRefGoogle Scholar
  2. Blackwell CA, Manning PJ, Hutchinson TC, Fisk SK (1974) Cranial hyperostosis of squirrel monkeys (Saimiri sciureus). Lab Anim Sci 24: 541–544PubMedGoogle Scholar
  3. De Klerk WA, du Plessis JP, Van der Watt JJ, Jager A, Laubscher NF (1973) Vitamin C requirements of the vervet monkey (Cercopithecus aethiops) under experimental conditions. S Afr Med J 47: 705–708PubMedGoogle Scholar
  4. Demaray SY, Altman HH, Ferrel TL (1978) Suspected ascorbic acid deficiency in a colony of squirrel monkeys (Saimiri sciureus). Lab Anim Sci 28: 457–460PubMedGoogle Scholar
  5. Friederici HHR, Taylor H, Rose R, Pirani CL (1966) The fine structure of capillaries in experimental scurvy. Lab Invest 15: 1442–1458PubMedGoogle Scholar
  6. Lehner NDM, Bullock BC, Clarkson TB (1968) Ascorbic acid deficiency in the squirrel monkey. Proc Soc Exp Biol Med 128: 512–514PubMedGoogle Scholar
  7. Machlin LJ, Garcia F, Kuenzig W, Brin M (1979) Anti-acorbutic activity of ascorbic acid phosphate in the rhesus monkey and the guinea pig. Am J Clin Nutr 32: 325–331PubMedGoogle Scholar
  8. Manning PJ, Wagner JE, Harkness JE (1984) Biology and diseases of guinea pigs. In: Fox JG, Cohen BJ, Lowe FM (eds) Laboratory animal medicine. Academic, Orlando, pp 149–181Google Scholar
  9. Nishikimi M, Udenfriend S (1976) Immunologic evidence that the gene for L-gulono-gama-lactone oxidase is not expressed in animals subject to scurvy. Proc Natl Acad Sci USA 73: 2066–2068PubMedCrossRefGoogle Scholar
  10. Ostergaard E, Loe H (1975) The collagen content of skin and gingival tissues in ascorbic acid-deficient monkeys. J Periodont Res 10: 103–114PubMedCrossRefGoogle Scholar
  11. Ratterree MS, Didier PJ, Blanchard JL, Clarke MR, Schaeffer D (1989) Vitamin C deficiency in captive nonhuman primates fed commercial primate diet. Lab Anim Sci 39: 101–106Google Scholar
  12. Richmond V, Stokstad ELR (1969) Effect of ascorbic acid on guinea pig skin collagen synthesis: I. Total collagen. J Dent Res 48/5:863–871Google Scholar
  13. Robbins SL, Cotran RS, Kumar V (eds) (1989) Pathologic basis of disease, 4th edn. Saunders, Philadelphia, pp 356–359Google Scholar
  14. Wolbach SB (1937) The pathologic changes resulting from vitamin deficiency. JAMA 108: 7–13CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1993

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  • E. Donald Roberts

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