Measles Virus Infection, Nonhuman Primates
The lesions of naturally occurring and experimental measles in nonhuman primates have been well described in the literature (Potkay et al. 1966; Scott and Keymer 1975; Hall et al. 1971; Sota and Deauville 1964; Manning et al. 1968; Blake and Trask 1921b; Lorenz and Albrecht 1980; Albrecht et al. 1980; Montrey et al. 1980; Levy and Mirkovic 1971; Taniguchi et al. 1954; Sergiev et al. 1960; Kamahora and Nii 1965). Facial edema and erythema accompanied by chemosis are common features on external examination (Fig. 112). In most species there is also an erythematous maculopapular rash on the ventral abdomen and inner thighs that often has a silvery scaly surface as it begins to fade (Fig. 113). Vesicles are rare, but pustules are occasionally present due to secondary bacterial infection. There may be one or more 1mm diameter, raised, white spots (Koplik spots), sometimes rimmed in red and with bluish centers, on the buccal, labial, or glossal mucosa; these usually precede the generalized rash and, if present, are pathognomonic for measles. Rash may be absent in some species or outbreaks, e.g., Colobus guereza (Hime et al. 1975) and Saguinus mystax (Albrecht et al. 1980). Death may precede the development of the rash or may occur after the rash has faded. Rash may be difficult to appreciate in darkly pigmented species, such as gorillas.
KeywordsPneumonia Diarrhea Dehydration Thrombocytopenia Proteinuria
Unable to display preview. Download preview PDF.
- Carter MJ, ter Meulen V (1990) Measles. In: Zuckerman AJ, Banatvala JE, Pattison JR (eds) Principles and practice of clinical virology, 2nd edn. Wiley, Chichester, pp 313–337Google Scholar
- McChesney MB, Fujinami RS, Lerche NW, Marx PA, Oldstone MBA (1989) Virus-induced immunosuppression: infection of peripheral blood mononuclear cells and suppression of immunoglobulin synthesis during natural measles virus infection of rhesus monkeys. J Infect Dis 159: 757–760PubMedCrossRefGoogle Scholar
- Mei A, Meng Y, Gouxiang L, Shufan C, Jingyn Z, Ping S (1990) Virological survey of rhesus monkeys in China. Lab Anim Sci 40: 29–32Google Scholar
- Pongrithsukda V, Phonboon K, Manunpichu K (1986) Measles-associated diarrhoea in northeastern Thailand. S E Asian J Trop Med Public Health 17: 43–47Google Scholar
- Sergiev PG, Ryazantseva NE, Shroit IG (1960) The dynamics of pathological processes in experimental measles in monkeys. Acta Virol 4: 265–273Google Scholar
- Shah KV, Southwick CH (1965) Prevalence of antibodies to certain viruses in sera of free-living rhesus and of captive monkeys. Ind J Med Res 53: 488–500Google Scholar
- Sota PJ, Deauville GA (1964) Spontaneous simian giant-cell pneumonia with coexistent B virus infection. Am J Vet Res 25: 793–804Google Scholar
- Taniguchi T, Kamahora J, Kato S, Hagiwara K (1954) Pathology in monkeys experimentally infected with measles virus. Med J Osaka Univ 5: 367–396Google Scholar