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Clinical Implications of Antibiotic-Induced Endotoxin Liberation

  • Conference paper
Book cover Yearbook of Intensive Care and Emergency Medicine 1993

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

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Abstract

Gram-negative bacteria cause the majority of fatal infections in developed countries, usually in association with septic shock or meningitis. The pathophysiology of gram-negative bacterial infection is thought to be mediated in large part by lipopolysaccharide (LPS), a toxin elaborated by all species of gram-negative bacteria [1]. LPS is a structural component of the gram-negative bacterial cell envelope, and is therefore known as endotoxin. Gram-positive bacteria do not synthesize LPS. The lack of LPS in the cell envelope of grampositive organisms versus its presence in the gram-negative envelope accounts for the difference in staining characteristics of these two major categories of bacteria.

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Authors
  1. J. L. Shenep
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1993 Springer-Verlag Berlin Heidelberg

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Shenep, J.L. (1993). Clinical Implications of Antibiotic-Induced Endotoxin Liberation. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_7

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  • DOI: https://doi.org/10.1007/978-3-642-84904-6_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56463-8

  • Online ISBN: 978-3-642-84904-6

  • eBook Packages: Springer Book Archive

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