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Yearbook of Intensive Care and Emergency Medicine 1993 pp 629–637Cite as

Consumptive Coagulopathies in the Critically III

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Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

Abstract

Trauma, shock, and sepsis are frequently complicated by coagulation disorders which contribute to the development of multiorgan failure [1]. Especially in trauma patients, intrinsic and extrinsic activation of the clotting cascade is started by the release of tissue factor and contact activation following vascular damage. In septic patients, lipopolysaccharides (LPS) accelerate procoagulant turnover by activating neutrophils and hence mediators like elastase or platelet activating factor (PAF), and factor XII. The application of cristalloids and colloids in order to maintain normovolemia further dilutes both the procoagulant and inhibitor potential of the plasmatic coagulation. Plasma factors and platelets are lost by traumatic, surgical or diffuse bleeding. However, with ongoing activation of the coagulation cascade, dilution and loss become less important compared to changes in the dynamics of procoagulant and inhibitor turnover.

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Authors
  1. R. Scherer
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  2. W. J. Kox
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1993 Springer-Verlag Berlin Heidelberg

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Scherer, R., Kox, W.J. (1993). Consumptive Coagulopathies in the Critically III. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_58

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  • DOI: https://doi.org/10.1007/978-3-642-84904-6_58

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56463-8

  • Online ISBN: 978-3-642-84904-6

  • eBook Packages: Springer Book Archive

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