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The Role of Endotoxin in Bacterial Septic Shock

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Yearbook of Intensive Care and Emergency Medicine 1993

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

Abstract

Endotoxin is a lipopolysaccharide (LPS) located in the outer membrane of gram-negative bacteria. Over the last 60 years, researchers have given endotoxin to animals and human volunteers to induce septic shock and investigate the pathophysiologic events associated with this Syndrome [1,2]. Recently, researchers evaluated the effects of antibody therapies directed against endotoxin in septic patients [3,4]. The inconclusive results of these studies have raised new questions about the role of endotoxin in live bacterial infections [5]. To help answer questions about endotoxin, we review its biochemistry, its possible role in human disease, and its relationship to clinical antibody therapies.

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Authors
  1. W. D. Hoffman
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  2. C. Natanson
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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Hoffman, W.D., Natanson, C. (1993). The Role of Endotoxin in Bacterial Septic Shock. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_5

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