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Effects of Critical Illness on Macrophage, T and B Cell Function

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1993

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

Abstract

In most circumstances, a productive interaction between T and B cells is necessary in achieving resistance to infection. An example of T-B cell Cooperation is seen in the immune response to bacterial infection, such as that caused by Pseudomonas aeruginosa or Streptococcus pneumoniae, where bacterial antigens first interact with Immunoglobulins on the surface of B cells. The bound bacterial antigens are internalized and processed by the B cells, so that they can be presented in a recognizablevmanner to T cells and engage the antigen specific T cell receptor (TCR) present on the membrane of the T cell. The T cells then become activated and can stimulate B cells to become plasma cells, capable of secreting large amounts of antibody directed to the invading bacteria.

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Authors
  1. E. Abraham
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1993 Springer-Verlag Berlin Heidelberg

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Abraham, E. (1993). Effects of Critical Illness on Macrophage, T and B Cell Function. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-84904-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56463-8

  • Online ISBN: 978-3-642-84904-6

  • eBook Packages: Springer Book Archive

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