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Calcium, Catecholamine Action, and Cardiovascular Function during Critical Illness

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1993

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

Abstract

Calcium is an essential ion for normal cellular function. It is important for excitation-contraction coupling, neurotransmission, axonal flow, hormone secretion, cell division, blood coagulation, enzyme activation, membrane integrity, wound repair, and ciliary motion. It is the primary regulator of cell events which involve movement. It is a key intracellular messenger coupling cell receptor activation to intracellular biochemicall events. Because of its importance to cellular activity and organ function, maintenance of normal calcium homeostasis has been a goal of the practicing clinician. This has been accomplished by measuring calcium concentrations in the blood and administering exogenous calcium when levels are low. However, recent experimental data suggest that calcium administration may be harmful during ischemic and septic states. These diseases are characterized by low circulating calcium levels but elevated free intracellular calcium concentrations. Calcium administration further increases intracellular calcium and may interfere with cellular function (i.e. activate digestive enzymes, interfere with intracellular messengers).

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Authors
  1. G. P. Zaloga
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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Zaloga, G.P. (1993). Calcium, Catecholamine Action, and Cardiovascular Function during Critical Illness. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_32

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  • DOI: https://doi.org/10.1007/978-3-642-84904-6_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56463-8

  • Online ISBN: 978-3-642-84904-6

  • eBook Packages: Springer Book Archive

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