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Interaction of Tumor Necrosis Factor/ Cachectin and Nutrition

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1993

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

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Abstract

The critically ill septic patient often exhibits profound and accelerated signs of nutritional deficiency. Hypermetabolism, wasting with nitrogen loss, hypoalbuminemia, increased levels of acute-phase proteins, hyperglycemia, hyperlipidemia and intolerance to nutrients have all been observed [1]. However, the ability to nourish these patients is often hindered because of altered nutrient metabolism [2]. It is now increasingly being recognized that cytokines [3], especially cachectin (TNF) [4], interleukin-1 (IL-1) and IL-6, are either associated with sepsis or are the mediators of a number of metabolic phenomena observed in sepsis [5-15], including anorexia, fever, hypotension, somnolence, acute-phase protein synthesis, abnormalities of lipid and glucose metabolism. Sepsis is often associated with malnutrition, and TNF as well as IL-6 have been shown to cause wasting due to metabolic effects and/or anorexia [12,13,16–21]. However it should be recognized that TNF can induce the production of both IL-1 and IL-6 [22,23]. In clinical sepsis, the release of hormones in response to shock and endotoxin may add to the metabolic events.

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Authors
  1. K. N. Jeejeebhoy
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1993 Springer-Verlag Berlin Heidelberg

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Jeejeebhoy, K.N. (1993). Interaction of Tumor Necrosis Factor/ Cachectin and Nutrition. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_19

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  • DOI: https://doi.org/10.1007/978-3-642-84904-6_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56463-8

  • Online ISBN: 978-3-642-84904-6

  • eBook Packages: Springer Book Archive

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