Administration of Human Growth Hormone in Critically Ill Patients

  • H. J. Voerman
  • L. G. Thijs
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine 1993 book series (YEARBOOK, volume 1993)


Trauma, sepsis, surgery and hypocaloric feeding all increase catabolic rate, resulting in a loss of body protein. Both the increase in metabolic rate and proteolysis are thought to result from hormonal changes and the production of mediators. Prevention of erosion of lean body mass may result in shorter weaning periods from mechanical Ventilation and reconvalescense periods. Furthermore, protein loss is associated with loss of immunocompetence, increased incidence of infection, poor wound healing, muscle weakness, and even mortality. Amelioration of loss of body protein may thus improve patient outcome. Aggressive nutritional support is not effective in increasing or even maintaining body protein. Research has therefore focused on adjunctive therapy to enteral and parenteral nutrition.


Growth Hormone Parenteral Nutrition Human Growth Hormone Nitrogen Balance Renal Plasma Flow 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • H. J. Voerman
  • L. G. Thijs

There are no affiliations available

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