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Administration of Human Growth Hormone in Critically Ill Patients

  • Conference paper
Book cover Yearbook of Intensive Care and Emergency Medicine 1993

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

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Abstract

Trauma, sepsis, surgery and hypocaloric feeding all increase catabolic rate, resulting in a loss of body protein. Both the increase in metabolic rate and proteolysis are thought to result from hormonal changes and the production of mediators. Prevention of erosion of lean body mass may result in shorter weaning periods from mechanical Ventilation and reconvalescense periods. Furthermore, protein loss is associated with loss of immunocompetence, increased incidence of infection, poor wound healing, muscle weakness, and even mortality. Amelioration of loss of body protein may thus improve patient outcome. Aggressive nutritional support is not effective in increasing or even maintaining body protein. Research has therefore focused on adjunctive therapy to enteral and parenteral nutrition.

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References

  1. Rennie MJ (1985) Muscle protein turnover and the wasting due to injury and disease. Brit Med Bull 41: 257–264

    PubMed  CAS  Google Scholar 

  2. Fryburg DA, Gelfand RA, Barrett EJ (1991) Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. Am J Physiol 260: E499–E504

    PubMed  CAS  Google Scholar 

  3. Moller N, Jorgensen JOL, Alberti KGMM, Flyvbjerg A, Schmitz O (1990) Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab 70: 1179–1186

    Article  PubMed  CAS  Google Scholar 

  4. Feiig P, Marliss EB, Cahill GF (1971) Metabolic response to human growth hormone during prolonged starvation. J Clin Invest 50: 411–421

    Article  Google Scholar 

  5. Zapf J, Froesch ER (1986) Pathophysiological and clinical aspects of the insulin-like growth factors. Hormone Res 24: 160–165

    Article  PubMed  CAS  Google Scholar 

  6. Manson JMck, Smith RJ, Wilmore DW (1988) Growth hormone stimulates protein synthesis during hypocaloric parenteral nutrition. Ann Surg 208: 136–142

    Article  PubMed  CAS  Google Scholar 

  7. Lundeberg S, Beifrage M, Wernerman J, von der Decken A, Thunell S, Vinnars E (1991) Growth hormone impoves muscle protein metabolism and whole body nitrogen economy in man during a hyponitrogenous diet. Metabolism 40: 315–322

    Article  PubMed  CAS  Google Scholar 

  8. Snyder DK, Underwood LE, Clemmons DR (1990) Anabolic effects of growth hormone in obese diet-restricted subjects are dose dependent. Am J Clin Nutr 52: 431–437

    PubMed  CAS  Google Scholar 

  9. Snyder DK, Clemmons DR, Underwood LE (1988) Treatment of obese, diet restricted subjects with growth hormone for 11 weeks: Effects on anabolism, lipolysis, and body composition. J Clin Endocrinol Metab 67: 54–55

    Article  PubMed  CAS  Google Scholar 

  10. Ziegler TR, Young LS, Manson JM (1988) Metabolic effects of recombinant human growth hormone in patients receiving parenteral nutrition. Ann Surg 208: 6–16

    Article  PubMed  CAS  Google Scholar 

  11. Parker DC, Rossman LG, Siler TM, Rivier J, Yen SSC, Guillemin R (1974) Inhibition of the sleep-related peak in physiologic human growth hormone release by somatostatin. J Endocrinol Metab 38: 496–499

    Article  CAS  Google Scholar 

  12. Kaiser FE, Silver AJ, Morley JE (1991) The effect of recombinant human growth hormone on malnourished older individuals. J Am Geriatr Soc 39: 235–240

    PubMed  CAS  Google Scholar 

  13. Suchner U, Rothkopf MM, Stanislaus G, Elwyn DH, Kvetan V, Askinazi J (1990) Growth hormone and pulmonry disease. Metabolic effect in patients receiving parenteral nutrition. Arch Int Med 150: 1225–1230

    Article  CAS  Google Scholar 

  14. Pape GS, Friedman M, Underwood LE, Clemmons DR (1991) The effect of growth hormone on weight gain and pulmonary function in patients with chronic obstructive lung disease. Chest 99: 1495–1500

    Article  PubMed  CAS  Google Scholar 

  15. Douglas RG, Humberstone DA, Haystead A, Shaw JHF (1990) Metabolic effects of recombinant human growth hormone: Isotopic studies in the postabsorptive State and during total parenteral nutrition. Br J Surg 77: 785–790

    Article  PubMed  CAS  Google Scholar 

  16. Ward HC, Halliday D, Sim AJW (1987) Protein and energy metabolism with biosynthetic human growth hormone after gastrointestinal surgery. Ann Surg 206: 56–61

    Article  PubMed  CAS  Google Scholar 

  17. Ponting GA, Halliday D, Teale JD, Sim AJW (1988) Postoperative positive nitrogen balance with intravenous hyponutrition and growth hormone. Lancet 1: 438–439

    Article  PubMed  CAS  Google Scholar 

  18. Ponting GA, Ward HC, Halliday D, Sim AJW (1990) Protein and energy metabolism with bio-synthetic human growth hormone in patients on füll intravenous nutritional support. JPEN 14: 437–441

    Article  CAS  Google Scholar 

  19. Lehmann SL, Teasley KM, Konstantinidis NN, Konstantinidis K, Cerra FB (1990) Growth hormone enables effective nutrition by peripheral vein in postoperative patients: A pilot study. J Am Coli Nutr 9: 610–615

    CAS  Google Scholar 

  20. Piccolboni D,, de Vincentiis L, Guerriero G et al. (1991) Nutritional and hormonal effects of biosynthetic human growth hormone in surgical patients on total parenteral nutriton. Nutrition 7: 177–184

    PubMed  CAS  Google Scholar 

  21. Mjaaland M, Unneberg K, Hotvedt R, Revhaug A (1991) Nitrogen retention caused by growth hormone in patients undergoing gastrointestinal surgery with epidural analgesia and parenteral nutrition. Eur J Surg 157:21–27

    PubMed  CAS  Google Scholar 

  22. Wilmore DW, Moylan JA, Bristow BF, Mason AD, Pruitt BA (1974) Anabolic effects of human growth hormone and high caloric feedings following thermal injury. Surg Gynecol Obstet 138:875–884

    PubMed  CAS  Google Scholar 

  23. Ziegler TR, Young LS, Ferrari-Baliviera E, Demling RH, Wilmore DW (1990) Use of human growth hormone combined with nutritional support in a critical care unit. JPEN 14:574–581

    Google Scholar 

  24. Belcher HJCR, Mercer D, Judkins KC, et al. (1989) Biosynthetic human growth hormone in burn patients: A pilot study. Burns 15:99–107

    Article  PubMed  CAS  Google Scholar 

  25. Johnston IDA, Hadden DR (1963) Effect of human growth hormone on the metabolic response to surgical trauma. Lancet 1:584–586

    Article  Google Scholar 

  26. Ziegler TR, Rombeau JL, Young LS, et al. (1992) Recombinant human growth hormone enhances the metabolic efficacy of parenteral nutrition: A double-blind, randomized controlled trial. J Clin Endocrinol Metab 74:865–873

    Article  PubMed  CAS  Google Scholar 

  27. Jiang ZM, He GZ, Wang SI, Yang NF, Zhu Y, Wilmore DW (1989) Low dose growth hormone and hypocaloric nutrition attenuate the protein catabolic response after major Operation. Ann Surg 210:513–524

    Article  PubMed  CAS  Google Scholar 

  28. Okamura K, Okuma T, Tabira Y, Miyaughi Y (1989) Effect of administered human growth hormone on protein metabolism in septic rats. JPEN 13:450–454

    Article  Google Scholar 

  29. Dahn MS, Lange MP, Jacobs LA (1988) Insulin like growth factor 1 production is inhibited in human sepsis. Arch Surg 123:1409–1414

    Article  PubMed  CAS  Google Scholar 

  30. Gottardis M, Hackl JM (1988) Die Beeinflussung des katabolen Stoffwechsels bei Septischen Patienten und Schädel-Hirn-traumatisierten durch Gabe von humanen Wachstumshormon. Infusionstherapie 15:112–117

    Google Scholar 

  31. Voerman HJ, Strack van Schijndel RJM, Groeneveld ABJ, et al. (1992) Effects of recombinant human growth hormone in patients with severe sepsis. Ann Surg (in press)

    Google Scholar 

  32. Kimbrouhg TD, Shernan S, Ziegler TR, Scheltinga M, Wilmore DW (1991) Insulin-like growth factor-1 response is eomparable following intravenous and subcutaneous administration of growth hormone. J Surg Res 51:472–476

    Article  Google Scholar 

  33. Grunfeld C, Sherman BM, Cavalieri RR (1988) The acute effects of human growth hormone administration on thyroid function in normal men. J Clin Endocrinol Metab 67:1111–1114

    Article  PubMed  CAS  Google Scholar 

  34. Brent GA, Hersman JM (1986) Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration. J Clin Endocrinol Metab 63:1–7

    Article  PubMed  CAS  Google Scholar 

  35. Vandenburgh HH, Karlisch P, Shansky J, Feldstein R (1991) Insulin and IGF-1 induce pro nounced hypertrophy of skeletal muscle in tissue culture. Am J Physiol 260:C475–C484

    Google Scholar 

  36. Thuessen L, Christiansen JS, Sorensen KE, Jorgensen JOL, Orskov H, Henningsen P (1988) Increased myocardial eontractility following growth hormone administration in normal man. Dan Med Bull 35:193–196

    Google Scholar 

  37. Cuneo RC, Wilmshurst P, Lowy C, McGauley G, Sonksen PH (1989) Cardiac failure responding to growth hormone. Lancet 1:838–839

    Google Scholar 

  38. Rubin SA, Buttric P, Malhotra A, Melmed S, Fishbein MC (1990) Cardiac physiology, biochemistry and morphology in response to excess growth hormone in the rat. J Mol Cell Cardiol 22:429–438

    Article  PubMed  CAS  Google Scholar 

  39. Hischberg R, Kopple JD (1987) Effects of growth hormone on GFR and renal plasma flow in man. Kidney Int 32:S21–S24

    Google Scholar 

  40. Sherman SK, Demling RH, Lalonde C, Lowe DK, Eriksson E, Wilmore DW (1989) Growth hormone enhances reepithelialization of human split-thickness skin graft donor sites. Surg Forum 40:37–39

    Google Scholar 

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Authors
  1. H. J. Voerman
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  2. L. G. Thijs
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1993 Springer-Verlag Berlin Heidelberg

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Voerman, H.J., Thijs, L.G. (1993). Administration of Human Growth Hormone in Critically Ill Patients. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_15

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  • DOI: https://doi.org/10.1007/978-3-642-84904-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56463-8

  • Online ISBN: 978-3-642-84904-6

  • eBook Packages: Springer Book Archive

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