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Liver-Lung Interactions in ARDS with MOF

  • G. M. Matuschak
  • A. J. Lechner
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine 1993 book series (YEARBOOK, volume 1993)

Abstract

Multiple organ failure is a complex process occurring in up to 15% of patients in the intensive care unit (ICU) after initially successful resuscitation from severe infection, generalized activation of acute inflammatory responses (e. g. acute pancreatitis), or trauma [1–4]. Recently, this process has been termed the multiple organ dysfunction Syndrome (MODS), in view of the difficulties in distinguishing organ dysfunction from “failure” [1–3]. Despite application of progressively sophisticated diagnostic techniques and supportive care, the incidence of MODS is rising. More patients are elderly and immunocompromised, and undergo increasingly invasive procedures or therapeutic immunosuppression [1]. Case-specific mortality rates still ränge from 60–100% depending on patient age, pre-existing health status, number of organ systems involved, and the duration of organ impairment [3, 4]. Numerical aspects of organ dysfunction during MODS are strongly associated with mortality, independent of individual organ Performance [4]. However, the attendant notion of “organ equivalence” is no longer tenable with respect to their susceptibility to injury, involvement in systemic host defense regulation, and role in inducing cellular injury in remote organ systems owing to inappropriately regulated host responses.

Keywords

Systemic Inflammatory Response Syndrome Kupffer Cell Multiple Organ Dysfunction Syndrome Adult Respiratory Distress Syndrome Acute Inflammatory Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • G. M. Matuschak
  • A. J. Lechner

There are no affiliations available

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