Abstract
The differential diagnosis of acute liver disease occurring in the patient with neoplastic disease treated with either chemotherapy or transplantation is extensive (Table 1). Recurrence of primary disease, drug-induced liver disease, vascular disease including veno-occlusive disease, Budd-Chiari syndrome, infarction, graft-versus-host disease, and infection may all occur. The major infectious causes of liver disease include hepatitis B, hepatitis C, cytomegalovirus, and hepatosplenic candidiasis. Additionally, multiple types of hepatic injury may coexist, thereby potentiating the extent of liver cell injury and increasing the severity of clinical illness.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brillanti S, Garson JA, Tuke PW et al. (1991) Effect of alpha-interferon therapy on hepatitis C viraemia in community-acquired chronic non-A, non-B hepatitis: a quantitative polymerase chain reaction study. J Med Virol 34: 136–141
Davies SE, Portmann BC, O’Grady JG et al. (1991) Hepatic histological findings after transplantation for chronic hepatitis B virus infection, including a unique pattern of fibrosing cholestatic hepatitis. Hepatology 13: 150–157
Davis GL (1989) Interferon treatment of viral hepatitis in immunocompromised patients. Semin Liver Dis 9: 267–272
Davis GL (1991a) Chronic hepatitis. In: Kaplowitz N (ed) Liver and biliary diseases. Williams and Wilkins, Baltimore
Davis GL (1991b) Hepatitis C virus. In: Mandell GL, Douglas RG, Bennett JE (eds) Principles and practice of infectious diseases. Churchill Livingstone, New York, pp 3–11
Davis GL, Hoofnagle JH, Waggoner JG (1984) Spontaneous reactivation of chronic hepatitis B virus infection. Gastroenterology 86: 230–235
Davis GL, Balart LA, Schiff ER et al. (1989) Treatment of chronic hepatitis C with recombinant alfa interferon: a multicenter randomized controlled trial. N Engl J Med 321: 1501–1506
Dienstag JL (1983) Non-A, non-B hepatitis: I. Recognition, epidemiology, and clinical features. Gastroenterology 85: 439–462
Dusheiko G, Song E, Bowyer S et al. (1983) Natural history of hepatitis B virus infection in renal transplant recipients - a fifteen year follow-up. Hepatology 3: 330–336
Ferrari C, Penna A, DegliAntoni A, Fiaccardori F (1988) Cellular immune response to hepatitis B virus antigens: an overview. J Hepatol 7: 21–33
Hoofnagle JH, Dusheiko GM, Seeff LB et al. (1981) Seroconversion from hepatitis Be antigen to antibody in chronic type B hepatitis. Ann Intern Med 94: 744–748
Hoofnagle JH, Davis GL, Hanson RG et al. (1986) A short course of prednisolone in chronic type B hepatitis: report of a randomized double-blind placebo-controlled trial. Ann Intern Med 104: 12–16
Korenman J, Baker B, Waggoner J et al. (1991) Long-term remission of chronic hepatitis B after alpha-interferon therapy. Ann Intern Med 114: 629–634
Martin P, DiBisceglie AM, Kassianides C (1989) Rapidly progressive non-A, non-B hepatitis in patients with human immunodeficiency virus infection. Gastroenterology 97: 1559–1561
Perrillo RP, Schiff ER, Davis GL et al. (1991) A randomized, controlled study of interferon alfa, alone and following prednisone withdrawal, in the treatment of chronic hepatitis B. N Engl J Med 323: 295–301
Pinto PC, Hu E, Bernstein-Singer M, Pinter-Brown L, Govindarajan S (1990) Acute hepatic injury after withdrawal of immunosuppressive chemotherapy in patients with hepatitis B. Cancer 65: 878–884
Reinke P, David H, Scholz D (1987) The significance of liver changes as the cause of death in kidney transplant patients: an analysis of 689 autopsy cases. Zentralbl Allg Pathol 133: 447–452
Seeff LB (1990) Diagnosis, therapy, and prognosis of viral hepatitis. In: Zakim D, Boyer TD (eds) Hepatology: a textbook of liver disease, 2nd edn. Saunders, Philadelphia, pp 958–1025
Tur-Kaspa R, Burk RD, Shaul Y, Shafritz DA (1986) Hepatitis B virus contains a glucocorticoid responsive element. Proc Natl Acad Sci USA 83: 1627–1631
Wands JR, Walker JA, Davis TT et al. (1974) Hepatitis B in an oncology unit. N Engl J Med 29: 1371–1375
Weimar W, Kramer P, Bijnen AB et al. (1985) The incidence of cytomegalo- and herpes simplex virus infections in renal allograft recipients treated with high-dose recombinant leukocyte interferon: a controlled study. Scand J Urol Nephrol 92 [Suppl]: 37–39
Further Reading
Davis GL (1989) Interferon treatment of viral hepatitis in immunocompromised patients. Semin Liver Dis 9:267–272 Review of the natural history and treatment of viral hepatitis in immunocompromised patients.
Davis GL, Balart LA, Schiff ER et al. (1989) Treatment of chronic hepatitis C with recombinant alfa interferon: a multicenter randomized controlled trial. N Engl J Med 321:1501–1506 Report of large multicenter study which documented effectiveness of treatment of chronic non-A, non-B hepatitis (hepatitis C) with recombinant interferon alfa2b.
Pinto PC, Hu E, Bernstein-Singer M, Pinter-Brown L, Govindarajan S (1990) Acute hepatic injury after withdrawal of immunosuppressive chemotherapy in patients with hepatitis B. Cancer 65:878–884 Report of cases and discussion of post-chemotherapy liver failure due to activation of hepatitis B.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Davis, G.L. (1993). Hepatitis B and C: Influence of Immunosuppression. In: Schimpff, S.C., Klastersky, J. (eds) Infectious Complications in Bone Marrow Transplantation. Recent Results in Cancer Research, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84899-5_22
Download citation
DOI: https://doi.org/10.1007/978-3-642-84899-5_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-84901-5
Online ISBN: 978-3-642-84899-5
eBook Packages: Springer Book Archive