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Graft-Versus-Host Disease: Basic Considerations

  • Conference paper
Infectious Complications in Bone Marrow Transplantation

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 132))

Abstract

Despite modern matching techniques graft-versus-host disease (GVHD) remains one of the major complications of bone marrow transplantation (BMT). It occurs in up to 80% of patients receiving HLA-matched sibling BMT and is responsible directly or indirectly for about 20% of the mortality seen after BMT. Prevention and treatment of GVHD is only partially successful at present because of both the inefficiency and lack of specificity of treatment. Here the immunopathology of acute and chronic GVHD, and its relationship with infection, is discussed.

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References

Further Reading

  • Atkinson KA (1990) Chronic Graft-versus-host disease - review. Bone Marrow Transplant 5:69–82 This is an excellent review of the clinical and pathological features and treatment of chronic GVHD.

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Author information

Authors and Affiliations

  1. Department of Haematology, Royal Postgraduate Medical School, University of London, Hammersmith Hospital, Ducane Road, London, W120NN, UK

    A. J. Barrett

Authors
  1. A. J. Barrett
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Editor information

Editors and Affiliations

  1. University of Maryland Medical System, 21201, Baltimore, MD, USA

    Stephen C. Schimpff M.D.

  2. Institut Jules Bordet, Centre des Tumeurs de l’Université Libre de Bruxelles, Brussels, Belgium

    Jean Klastersky M.D.

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© 1993 Springer-Verlag Berlin · Heidelberg

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Barrett, A.J. (1993). Graft-Versus-Host Disease: Basic Considerations. In: Schimpff, S.C., Klastersky, J. (eds) Infectious Complications in Bone Marrow Transplantation. Recent Results in Cancer Research, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84899-5_19

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  • DOI: https://doi.org/10.1007/978-3-642-84899-5_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84901-5

  • Online ISBN: 978-3-642-84899-5

  • eBook Packages: Springer Book Archive

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