Bone Marrow Transplantation for Cancer: An Overview
Although allogeneic bone marrow transplantation has been attempted for over 50 years (Bortin 1970), it was not until 1968 that the first successful transplant was achieved in a child with an immunodeficiency syndrome (Gatti et al. 1968). Since that time, allogeneic, and more recently autologous, transplantation has grown repidly as a means of treating a variety of malignant and nonmalignant disorders. In a recent survey conducted by the International Bone Marrow Transplant Registry (IBMTR), data from 342 institutions in 47 countries revealed that 14745 patients had been treated with either allogeneic or syngeneic transplants during the years 1988–1990 (Bortin et al. 1992). Overall, it is estimated that over 32500 allogeneic or syngeneic transplants have been performed worldwide since the first successful transplant.
KeywordsHepatitis Lymphoma Leukemia Oncol Diarrhea
Unable to display preview. Download preview PDF.
- Advisory Committee of the International Autologous Bone Marrow Transplant Registry (1989) Autologous bone marrow transplants: different indications in Europe and America. Lancet ii: 317–318Google Scholar
- Ash R, Horowitz MM, Gale RP, van Bekkum DW, Casper JY, Gordon-Smith EC, Henslee-Downey PJ, Kolb JH, Lowenberg B, Masaoka T, McGlave PB, Rimm AA, Ringdén O, van Rood JJ, Sondel PM, Vowels Mr, Bortin MM (1991) Bone marrow transplantation from related donors other than HLA-identical siblings: effect of T-cell depletion. Bone Marrow Transplant 7: 443–452PubMedGoogle Scholar
- Gorin NC, Aegerter P, Auvert B, Meloini G, Goldstone AH, Burnett A, Carella A, Korbling M, Herve P, Maraninchi D, Löwenberg R, Verdonck LF, de Planque M, Hermans J, Helbig W, Porcellini A, Rizzoli V, Alesandrino EP, Franklin IM, Reifiers J, Collesslli P, Goldman JM (1990) Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: a European survey of the role of marrow purging. Blood 75: 1606–1614PubMedGoogle Scholar
- Nemunaitis J, Rabinowe SN, Singer Jw, Bierman Pj, Vose Jm, Freedman AS, Onetto N, Gillis S, Oette D, Gold M, Duckner CD, Hansen JA, Ritz J, Applebaum FR, Armitage JO, Nadler LM (1991) Recombinant granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid cancer. N Engl J Med 324: 1773–1778PubMedCrossRefGoogle Scholar
- Thomas ED, Buckner CD, Banaji M, Clift RA, Fefer A, Flournoy N, Goodell BW, Hickman HO, Lerner KG, Neiman PE, Sale GE, Śanders JE, Singer J, Stevens M, Storb R, Weiden PL (1977) One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. Blood 49: 511–533PubMedGoogle Scholar