Multiparameter Analysis of Blast Cells in Patients with Acute Leukemia Following a Primary Myelodysplastic Syndrome
The blast cells in acute leukemia following myelodysplastic syndrome (MDS) have classically been assumed to be of myeloid lineage (Tricot et al. 1985). However, our previous preliminary data (San Miguel et al. 1986b) as well as several case reports have shown that other cell lineages, including the lymphoid, may occasionally be involved in these leukemia’s (Barton et al. 1980; Berneman et al. 1985; Eridani et al. 1985). Moreover, to the best of our knowledge the only broad molecular genetic study in MDS patients is that reported by Wainscoat et al. (1988), showing an absence of immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangement. However, the appearance of new cell clones in the acute transformation of MDS may induce molecular changes that so far have not been analyzed.
KeywordsLeukemia Recombination Agarose Citrate Anemia
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