Multiparameter Analysis of Blast Cells in Patients with Acute Leukemia Following a Primary Myelodysplastic Syndrome
The blast cells in acute leukemia following myelodysplastic syndrome (MDS) have classically been assumed to be of myeloid lineage (Tricot et al. 1985). However, our previous preliminary data (San Miguel et al. 1986b) as well as several case reports have shown that other cell lineages, including the lymphoid, may occasionally be involved in these leukemia’s (Barton et al. 1980; Berneman et al. 1985; Eridani et al. 1985). Moreover, to the best of our knowledge the only broad molecular genetic study in MDS patients is that reported by Wainscoat et al. (1988), showing an absence of immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangement. However, the appearance of new cell clones in the acute transformation of MDS may induce molecular changes that so far have not been analyzed.
KeywordsChronic Myeloid Leukemia Acute Leukemia Myelodysplastic Syndrome Gene Rearrangement Blast Cell
Unable to display preview. Download preview PDF.
- Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnisk HR, Sultan C, The France-American-British (FAB) Group (1982) Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51: 189Google Scholar
- San Miguel JF, Tavares de Castro J, Matutes E, Rodriguez B, Polli N, Zola H, McMichael AJ, Bollum FJ, Thompson DS, Goldman JM, Catovsky D (1985) Characterization of blast cells in chronic granulocytic leukaemia in transformation, acute myelofibrosis and undifferentiated leukemias. Br J Haematol 59: 297PubMedCrossRefGoogle Scholar
- San Miguel JF, Hernández JM, González-Sarmiento R, González M, Sánchez I, Orfao A, Cañizo MC, López-Borrasca A (1991) Acute leukemia following a primary myelodysplastic syndrome: immunophenotypic, genotypic and clinical characteristics. Blood 78Google Scholar